Cephalopod Tissue Regeneration: Consolidating Over a Century of Knowledge.

Cephalopod Tissue Regeneration: Consolidating Over a Century of Knowledge.
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DOI:
10.3389/fphys.2018.00593
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发表时间:
2018
影响因子:
4
通讯作者:
Fiorito G
Fiorito G
中科院分区:
医学2区
文献类型:
--
作者:
Imperadore P;Fiorito G

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再生是一个由受损结构的再生和功能恢复组成的过程,广泛存在于从低等无脊椎动物到哺乳动物的动物界的几个门中。在有再生能力的物种中,恢复受损组织的完整形式和功能的实际能力差异很大,从能够进行全身和内部器官再生的物种到这种能力仅限于少数组织的情况。在无脊椎动物中,头足类软体动物保留了再生几种结构的能力(即,肌肉、神经或整个附肢)。在这里,我们提供了在过去160年的研究中进行的100多项研究的概述。尽管付出了巨大的努力,但头足类动物组织再生的许多方面,包括相关的分子和细胞机制,仍然在很大程度上未被探索。我们的方法在很大程度上是描述性的,旨在为以前的工作提供参考,从而促进未来的研究工作。我们相信这样的研究可能会导致重要的发现和方法,可应用于其他动物类群,包括高等脊椎动物,以及其他研究领域,如再生医学。
Regeneration, a process consisting in regrowth of damaged structures and their functional recovery, is widespread in several phyla of the animal kingdom from lower invertebrates to mammals. Among the regeneration-competent species, the actual ability to restore the full form and function of the injured tissue varies greatly, from species being able to undergo whole-body and internal organ regeneration, to instances in which this ability is limited to a few tissues. Among invertebrates, cephalopod mollusks retain the ability to regenerate several structures (i.e., muscles, nerves, or entire appendages). Here we provide an overview of more than one-hundred studies carried out over the last 160 years of research. Despite the great effort, many aspects of tissue regeneration in cephalopods, including the associated molecular and cellular machinery, remain largely unexplored. Our approach is largely descriptive and aims to provide a reference to prior work thus to facilitate future research efforts. We believe such research may lead to important discoveries and approaches that can be applied to other animal taxa including higher vertebrates, as well as other research fields such as regenerative medicine.
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