Long-term outlook for renal transplant recipients with one-year function. "Doctor, what are my chances"?
Long-term outlook for renal transplant recipients with one-year function. "Doctor, what are my chances"?
复制标题
具有一年功能的肾移植受者的长期前景。
DOI：
10.1097/00007890-199101000-00018
复制
发表时间：
1991
期刊：
影响因子：
6.2
通讯作者：
Najarian,JS
中科院分区：
文献类型：
--
作者：
Fischel,RJ;Payne,WD;Gillingham,KJ;Dunn,DL;Sutherland,DE;Matas,AJ;Najarian,JS
肾移植患者在第一年存活下来后，经常会询问长期功能的机会。我们研究了自1963年6月7日至1988年9月1日的1850例初次移植的患者，他们的移植物存活时间超过1年。患者按供体类型、糖尿病状况和是否接受环孢素A(CsA)进行分组。半衰期(T1/2)用于比较长期存活率。我们确定了移植物的长期存活率，包括有功能死亡(DWF)和排除死亡(DWF)，以便研究所有患者，并引导人们注意免疫损失。在CSA前，DWF是每个队列中移植物丢失的主要原因。引起DWF的原因是心血管疾病(49%)、感染(26%)和癌症(14%)。与CSA组相比，CSA前组患者发生DWF的比例要高得多：HL A相合的活体亲属捐献者，16%对3%；不相合的LRD，22%对5%；身体捐赠者，26%对11%。
Patients with renal transplants that survive the first year often ask about the chance of long-term function. We studied 1850 patients with primary transplants from June 7, 1963 to September 1, 1988 who had graft survival of greater than 1 year. Patients were grouped by donor type, diabetic status, and whether or not they received cyclosporine (CsA). Half-life (T1/2) was used to compare long-term survival rates. We determined the long-term graft survival inclusive and exclusive of death with function (DwF) in order to study all patients and to direct attention to immunologic losses. Pre-CsA, DwF was the major cause of graft loss in each cohort. Cause of DwF was cardiovascular (49%), infection (26%), and cancer (14%). The percentage of patients experiencing DwF was much higher in the pre-CsA group vs. the CsA group: HLA-identical living related donor, 16% vs. 3%; non-HLA-identical LRD, 22% vs. 5%; and cadaver donors, 26% vs. 11%.