Prognostic significance of serum thymidine phosphorylase concentration in esophageal squamous cell carcinoma
Prognostic significance of serum thymidine phosphorylase concentration in esophageal squamous cell carcinoma
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DOI：
10.1002/cncr.10418
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发表时间：
2002-04-01
期刊：
影响因子：
6.2
通讯作者：
Ochiai, T
中科院分区：
文献类型：
--
作者：
Shimada, H;Takeda, A;Ochiai, T
背景胸苷磷酸化酶（dThdlase），也称为血小板衍生的内皮细胞生长因子，是恶性肿瘤中血管生成的有效诱导剂。已发现增加的dThd 3表达和活性与各种实体瘤组织中的不良预后相关。由于对血清dThdR浓度（S-dThdR）的意义知之甚少，本研究旨在分析S-dThdR在食管鳞癌患者中的临床病理意义。采用酶联免疫吸附法测定了77例正常人和153例原发性食管鳞癌患者的S-dThdR。共80例患者接受了单纯手术; 46例患者接受了单纯放化疗; 17例患者接受了放化疗后手术; 10例患者未接受任何治疗。采用免疫组化法检测食管癌组织中胸苷磷酸化酶的表达。在80例单纯手术治疗的患者中确定了S-dThdR的临床病理价值和预后价值。食管癌患者的S-dThdR显著高于健康对照组（30.8 +/- 31.8 ng/mL vs. 13.8 +/- 7.6 ng/mL; P < 0.001）。根据肿瘤大小（P < 0.01）和肿瘤深度（P <0.01），观察到S-dThdPases的统计学显著差异。超过29.0 ng/mL的S-dThdR（代表健康对照组浓度的平均值加2个标准差）与dThdR表达（P = 0.022）、反应差（P = 0.022）和生存差（P < 0.01）相关。由于S-dThdR与肿瘤深度相关，S-dThdR不是独立的预后因素（P = 0.095）。高S-dThdR与肿瘤浸润深度和对治疗的不良反应相关。
BACKGROUND. Thymidine phosphorylase (dThdPase), which also is referred to as platelet-derived endothelial cell growth factor, is a potent inducer of angiogenesis in malignant tumors. Increased dThdPase expression and activity have been found to be associated with poor prognosis in various solid tumor tissues. Because very little was known about the significance of serum dThdPase concentration (S-dThdPase), the objective of this study was to analyze the clinicopathologic significance of S-dThdPase in the patients with esophageal squamous cell carcinoma.METHODS. The S-dThdPase was measured by enzyme-linked immunosorbent assay in 77 healthy controls and 153 patients with primary esophageal squamous cell carcinoma. A total of 80 patients underwent surgery alone; 46 patients received chemo radiotherapy alone; 17 patients received chemoradiotherapy followed by surgery; and 10 patients did not receive any treatment. Thymidine phosphorylase expression in esophageal carcinoma tissues was examined by immunohistochemistry. The clinicopathologic value and prognostic value of S-dThdPase was determined in 80 patients treated by surgery alone.RESULTS. The S-dThdPase is significantly higher in patients with esophageal carcinoma than in healthy controls (30.8 +/- 31.8 ng/mL vs. 13.8 +/- 7.6 ng/mL; P < 0.001). Statistically significant differences in S-dThdPases were observed depending on tumor size (P < 0.01) and tumor depth (P < 0.01). A S-dThdPase of more than 29.0 ng/mL (which represented the mean plus 2 standard deviation of the concentration in healthy controls) was associated with dThdPase expression (P = 0.022), poor response (P = 0.022), and poor survival (P < 0.01). Because S-dThdPase was associated with tumor depth, S-dThdPase was not an independent prognostic factor (P = 0.095).CONCLUSIONS. A high S-dThdPase is associated with depth of tumor invasion and poor response to treatment.