Gene Therapy for Cardiomyocyte Renewal: Cell Cycle, a Potential Therapeutic Target.
Gene Therapy for Cardiomyocyte Renewal: Cell Cycle, a Potential Therapeutic Target.
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DOI：
10.1007/s40291-022-00625-y
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发表时间：
2023-03
影响因子：
4
通讯作者：
Zhu, Wuqiang
中科院分区：
文献类型：
--
作者：
Son, Yura;Zhu, Wuqiang
心脏病是世界范围内的主要死亡原因。尽管已经进行了大量的研究，并且已经引入了许多药物和手术治疗来治疗心脏病，但死亡率仍然很高。基因治疗被广泛用于了解心肌梗死的分子机制和治疗心肌细胞丢失。据报道，成年心肌细胞以非常低的速率增殖，因此靶向其增殖已成为新的再生治疗靶点。目前，重新激活心肌细胞增殖似乎是促进成年心肌细胞更新的最有前途的方法之一。在这篇综述中，我们强调了目前正在追求的细胞增殖的基因治疗靶点，以重新激活心肌细胞的细胞周期，包括细胞周期调节因子，转录因子，微小RNA，信号转导和其他促成因素。我们还总结了已用于心脏研究的基因递送载体，以及在转化为临床方法和未来方向时需要克服的主要挑战。
Heart disease is the primary cause of death worldwide. Even though enormous research has been done, and many pharmacological and surgical treatments have been introduced to treat heart disease, the mortality rate still remains high. Gene therapy is widely used to understand molecular mechanisms of myocadiac infarction and to treat cardiomyocyte loss. It was reported that adult cardiomyocytes proliferate at a very low rate, thus targeting their proliferation has become a new regenerative therapeutic target. Currently, re-activating cardiomyocyte proliferation seems one of the most promising methods to promote adult cardiomyocyte renewal. In this review, we highlight gene therapeutic targets of cell proliferation presently being pursued to re-activate the cell cycle of cardiomyocytes, including cell cycle regulators, transcription factors, micro RNAs, signal transduction, and other contributing factors. We also summarize gene delivery vectors that have been used in cardiac research and ongoing major challenges to be overcome in the translation to the clinical approach and future directions.
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