CHARACTERIZATION OF REACTIVATION OF CYTOMEGALOVIRUS RETINITIS IN PATIENTS HEALED AFTER TREATMENT WITH HIGHLY ACTIVE ANTIRETROVIRAL THERAPY
CHARACTERIZATION OF REACTIVATION OF CYTOMEGALOVIRUS RETINITIS IN PATIENTS HEALED AFTER TREATMENT WITH HIGHLY ACTIVE ANTIRETROVIRAL THERAPY
复制标题
采用高活性抗逆转录病毒疗法治疗后痊愈的患者巨细胞病毒性视网膜炎再激活的特征
DOI：
10.1097/00006982-200002000-00007
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
W. Freeman
中科院分区：
文献类型：
--
作者：
Mi;M. P. Karavellas;D. Plummer;W. Freeman
Purpose: To delineate the immune parameters associated with reactivation of cytomeg‐alovirus (CMV) retinitis in patients for whom highly active antiretroviral therapy (HAART) was not successful. Methods: Prospective, longitudinal observational study of a cohort of 102 patients with CMV retinitis treated with HAART and being followed up at the AIDS Ocular Research Unit of the University of California, San Diego from November 1995 to November 1998. The study included serial clinical and fundus photographic examinations with CD4 T‐lympho‐cyte counts and HIV viral load measurements. Results: Forty‐seven of the 102 patients with CMV retinitis responded to HAART. Thirty‐five of the patients were successfully withdrawn from anti‐CMV therapy. During a median follow‐up of 74.71 weeks (range, 4.86‐144 weeks) after discontinuation of anti‐CMV therapy, four patients experienced a reactivation of CMV retinitis. In each case, the CD4 count decreased before reactivation to a median of 31.5 cells/mm3 (mean, 31.25 cells/mm3; range, 23‐39 cells/mm3). The association between the CD4 count decreasing to less than 50 cells/mm3 and reactivation of CMV retinitis was statistically significant (P < 0.0003). Conclusion: Four patients treated with HAART experienced reactivation of CMV retinitis as their CD4 count decreased. The threshold CD4 count below which reactivation of CMV retinitis occurred in patients for whom HAART was not successful appeared to be 50 cells/mm3. Despite an initial response to HAART, patients are still at risk for reactivation of CMV retinitis if their CD4 count decreases to less than 50 cells/mm3. The HIV viral load did not appear to predict CMV reactivation.
