Effect of weight loss on markers of triglyceride-rich lipoprotein metabolism in the metabolic syndrome
Effect of weight loss on markers of triglyceride-rich lipoprotein metabolism in the metabolic syndrome
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DOI：
10.1111/j.1365-2362.2008.02019.x
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发表时间：
2008-10-01
影响因子：
5.5
通讯作者：
Barrett, P. H. R.
中科院分区：
文献类型：
--
作者：
Chan, D. C.;Watts, G. F.;Barrett, P. H. R.
背景高脂血症是代谢综合征（MetS）中血脂异常的一个一致特征，与腹部脂肪量的程度和脂肪细胞因子分泌的改变有关。我们确定了减肥的影响，饮食限制标志物的富胆固醇脂蛋白（TRL）代谢和血浆脂肪cytokines.Design 35名男子与代谢综合征参加了为期16周的随机对照饮食干预研究。结果与体重维持组（n = 15）相比，体重减轻组（n = 20）的体重、血浆胰岛素、甘油三酯、总胆固醇、总脂联素、高分子量（HMW）脂联素和视黄醇结合蛋白-4（RBP-4）浓度均显著降低（P < 0. 05）。低密度脂蛋白胆固醇和脂甾醇（P < 0.05）。体重减轻还降低了血浆apoC-III（-33%）、apoB-48（-37%）、极低密度脂蛋白（VLDL）-apoB（-43%）、RLP-胆固醇（-48%）和RBP-4（-20%）浓度，并显著增加了血浆总（+20%）和HMW-脂联素（+19%）浓度。在体重减轻组中，血浆apoC-III的降低与血浆apoB-48、VLDL-apoB、RLP-胆固醇和甘油三酯的降低相关（P < 0.05）。血浆VLDL-apoB和甘油三酯水平降低与总脂联素水平升高相关（P < 0.05）。HMW-脂联素和RBP-4的变化与血浆apoB-48、apoC-III、VLDL-apoB、RLP-胆固醇或甘油三酯的变化无关。在多元回归分析，包括内脏脂肪，胰岛素和总脂联素浓度的变化，血浆apoC-III浓度的下降是一个独立的预测血浆apoB-48，VLDL-apoB，RLP-胆固醇和甘油三酯concentration.Conclusions在男性代谢综合征，体重减轻降低血浆apoB-48，VLDL-apoB，RLP-胆固醇和甘油三酯浓度的降低。这种效应可能部分与血浆apoC-III和脂联素浓度的伴随变化有关，这些变化加速了TRL的催化。
Backgroud Hypertriglyceridaemia, a consistent feature of dyslipidaemia in the metabolic syndrome (MetS), is related to the extent of abdominal fat mass and altered adipocytokine secretion. We determined the effect of weight loss by dietary restriction on markers of triglyceride-rich lipoprotein (TRL) metabolism and plasma adipocytokines.Design Thirty-five men with MetS participated in a 16 week randomized controlled dietary intervention study. Apolipoprotein (apo) C-III, apoB-48, remnant-like particle (RLP)-cholesterol, total adiponectin, high-molecular weight (HMW) adiponectin, and retinol-binding protein-4 (RBP-4) concentrations were measured using immunoassays.Results Compared with weight maintenance (n = 15), weight loss (n = 20) significantly decreased body weight, plasma insulin, triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol and lathosterol (P < 0.05). Weight loss also decreased plasma concentrations of apoC-III (-33%), apoB-48 (-37%), very low-density lipoprotein (VLDL)-apoB (-43%), RLP-cholesterol (-48%), and RBP-4 (-20%), and significantly increased plasma total (+20%) and HMW-adiponectin (+19%) concentrations. In the weight loss group, reduction in plasma apoC-III was associated (P < 0.05) with reduction in plasma apoB-48, VLDL-apoB, RLP-cholesterol and triglycerides. Increase in total adiponectin was associated (P < 0.05) with the reduction in plasma VLDL-apoB and triglycerides. The changes in HMW-adiponectin and RBP-4 were not associated with changes in plasma apoB-48, apoC-III, VLDL-apoB, RLP-cholesterol or triglycerides. In multiple regression analysis including changes in visceral fat, insulin and total adiponectin concentrations, the fall in plasma apoC-III concentration was an independent predictor of the reductions in plasma apoB-48, VLDL-apoB, RLP-cholesterol and triglycerides concentrations.Conclusions In men with MetS, weight loss decreases the plasma concentrations of apoB-48, VLDL-apoB, RLP-cholesterol and triglycerides. This effect could partly relate to concomitant changes in plasma apoC-III and adiponectin concentrations that accelerate the catabolism of TRLs.