Brain activity associated with the rubber foot illusion
Brain activity associated with the rubber foot illusion
复制标题
与橡胶脚错觉相关的大脑活动
DOI：
10.1016/j.neulet.2020.134820
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发表时间：
2020
影响因子：
2.5
通讯作者：
A.
中科院分区：
文献类型：
--
作者：
Matsumoto;N.;Nakai;R.;Ino;T.;Mitani;A.
身体的内部表征通过与环境相互作用的感官信息不断更新。手的内部表征可以用橡胶手错觉（RHI）范式进行实验操作。在RHI期间的脑活动提供了深入了解的神经机制的基础上重建的内部代表的手。最近，RHI范式已被用于下肢，揭示了下肢也会诱发错觉（橡胶脚错觉; RFI）。然而，RFI的神经相关性仍然未知。我们使用功能性磁共振成像（fMRI）来检查RFI期间的大脑活动。44名健康志愿者参与了fMRI实验。在右侧RFI期间，在双侧内侧和额中回、左侧补充运动区、双侧顶下小叶、楔前叶、距状皮质和小脑半球以及蚓部和双侧丘脑中观察到激活显著增加。在左侧RFI期间，在双侧内侧、中间和上级额回;左侧额下回和补充运动区、双侧顶下小叶和颞中回以及左侧小脑半球、蚓部和双侧丘脑中观察到激活显著增加。联合分析显示，包括双侧额内侧回和额中回在内的前额叶皮层，包括双侧顶下小叶在内的顶叶皮层，以及包括双侧小脑半球和小脑蚓部在内的小脑，在右侧和左侧RFIs期间联合激活。RFI期间共激活脑区的分布与先前报道的RHI期间激活脑区的分布相似。这些脑区的共同激活可能与身体内部表征的重建有关。这些区域在RFI和RHI中都被激活的事实将对治疗内部身体表征紊乱的患者产生影响。
The internal representation of the body is constantly updated by sensory information based on interactions with the environment. The internal representation of the hand can be experimentally manipulated with the rubber hand illusion (RHI) paradigm. Brain activity during the RHI provides insight into the neural mechanisms underpinning the reconstruction of the internal representation of the hand. Recently, the RHI paradigm has been employed for the lower limb, revealing that the illusion is also induced in the lower limb (rubber foot illusion; RFI). However, the neural correlates of the RFI remain unknown. We used functional magnetic resonance imaging (fMRI) to examine brain activity during the RFI. Forty-four healthy volunteers participated in the fMRI experiment. Significant increases in activation were observed in the bilateral medial and middle frontal gyri, left supplemental motor area, bilateral inferior parietal lobuli, precunei, calcarine cortices, and cerebellar hemispheres; and in the vermis and bilateral thalami during the right RFI. During the left RFI, significant increases in activation were observed in the bilateral medial, middle, and superior frontal gyri; left inferior frontal gyrus and supplemental motor area, bilateral inferior parietal lobuli and middle temporal gyri, and in the left cerebellar hemisphere, vermis, and bilateral thalami. Conjunction analysis revealed that the prefrontal cortex including the bilateral medial and middle frontal gyri, parietal cortex including the bilateral inferior parietal lobuli, and cerebellum including the bilateral cerebellar hemispheres and vermis were conjointly activated during the right and left RFIs. The distribution of co-activated brain areas during the RFI was similar to the previously reported distribution of brain areas activated during the RHI. Co-activation of these brain areas may be associated with the reconstruction of the internal representation of the body. The fact that these areas are activated both in the RFI and RHI will have implications for the treatment of patients with disturbed internal bodily representation.