The Role of Cancer Stem Cells in Breast Cancer Initiation and Progression: Potential Cancer Stem Cell-Directed Therapies
The Role of Cancer Stem Cells in Breast Cancer Initiation and Progression: Potential Cancer Stem Cell-Directed Therapies
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DOI：
10.1634/theoncologist.2012-0163
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发表时间：
2012-11-01
期刊：
影响因子：
5.8
通讯作者：
Siziopikou, Kalliopi
中科院分区：
文献类型：
--
作者：
Economopoulou, Panagiota;Kaklamani, Virginia G.;Siziopikou, Kalliopi
最近的研究已经在人类乳腺和其他实体瘤中鉴定出一小群具有干细胞特性的高度致瘤性细胞，这些细胞被认为是肿瘤起始和维持的来源;这些细胞被称为癌症干细胞（CSC）。临床前数据表明，当前的乳腺癌治疗策略导致CSC富集，导致化疗和放疗耐药性，尽管与临床参数和预后的强相关性尚未确定。重要的是，通过有效靶向CSC来克服治疗失败可能是一种有吸引力的方法，可能会改善乳腺癌患者的临床结局。几项临床前研究提供了支持这一假设的有希望的结果。本文综述了CSC在乳腺癌复发和耐药中的作用，并讨论了目前CSC靶向治疗的尝试。肿瘤学家2012; 17：1394-1401
Recent studies have identified a small population of highly tumorigenic cells with stem cell properties in human breast and other solid tumors that are considered to be the source of tumor initiation and maintenance; these cells are referred to as cancer stem cells (CSCs). Preclinical data suggest that current breast cancer treatment strategies lead to CSC enrichment, contributing to chemotherapy and radiotherapy resistance, although a strong correlation with clinical parameters and prognosis is yet to be established. Importantly, overcoming treatment failure by effective targeting of CSCs may be an appealing approach, potentially leading to improved clinical outcomes for patients with breast cancer. Several preclinical studies provide promising results that support this hypothesis. The purpose of this review is to summarize the role of CSCs in breast cancer recurrence and resistance and to discuss current attempts of CSC targeting. The Oncologist 2012; 17: 1394-1401