The modes of action of juvenile hormones: some questions we ought to ask
The modes of action of juvenile hormones: some questions we ought to ask
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DOI：
10.1016/s0965-1748(00)00037-0
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发表时间：
2000-08-01
影响因子：
3.8
通讯作者：
Davey, KG
中科院分区：
文献类型：
--
作者：
Davey, KG
保幼激素是由咽侧体（corpus allatum，CA）分泌到血淋巴中，通过结合蛋白转运，通过细胞膜扩散进入细胞，CA产物可能通过类固醇超家族的核受体与基因组发生某种相互作用，可能站不住脚。为此，本报告审查了以下问题。有多少个JH？昆虫中是否有其他的JH来源？昆虫中是否存在具有JH活性的非法尼醇类化合物？JH是如何进入细胞的？CA的产品是有效的激素吗？有多少种行动方式？有多少受体？(C)2000爱思唯尔科技有限公司版权所有。
This paper argues that the current dogma that juvenile hormones are structurally unique and constitute a family of derivatives of farnesoic acid which are produced by the corpus allatum (CA), secreted into the hemolymph, frequently transported by binding proteins, enter cells by diffusion across the cell membrane and there the products of the CA interact in some way with the genome, probably via nuclear receptors of the steroid superfamily, may not be tenable. It does so by examining the following questions. How many JHs are there? Are there other sources of JH in insects? Are there non-farnesoids with JH activity in insects? How does JH get into cells? Is the product of the CA the effective hormone? How many modes of action are there? How many receptors are there? (C) 2000 Elsevier Science Ltd. All rights reserved.