Advances in glucocorticoid-induced osteoporosis.

Advances in glucocorticoid-induced osteoporosis.
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DOI:
10.1007/s11926-011-0173-y
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发表时间:
2011-06
影响因子:
5
通讯作者:
Lems, Willem F.
Lems, Willem F.
中科院分区:
医学2区
文献类型:
--
作者:
den Uyl, Debby;Bultink, Irene E. M.;Lems, Willem F.

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糖皮质激素诱导的骨质疏松症(GIOP)是糖皮质激素使用的最重要的副作用之一,因为它会导致骨折风险增加。近年来,许多已发表的研究集中在骨代谢的细胞和分子机制,GIOP的病理生理学,以及预防GIOP的干预措施。在这篇综述中,总结了GIOP的最新进展,特别是我们对GIOP机制的理解的最新进展,从而提高了对GIOP的认识,这可能会导致在不久的将来开发新的治疗方案。
Glucocorticoid-induced osteoporosis (GIOP) is one of the most important side effects of glucocorticoid use, as it leads to an increased risk of fractures. Recently, many published studies have focused on the cellular and molecular mechanisms of bone metabolism, the pathophysiology of GIOP, and the intervention options to prevent GIOP. In this review, recent advances in GIOP are summarized, particularly recent progress in our understanding of the mechanisms of GIOP resulting in improved insight that might result in the development of new treatment options in the near future.
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