B Cell Development and Maturation
B Cell Development and Maturation
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B 细胞发育和成熟。
DOI：
10.1007/978-981-15-3532-1_1
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Wang，Ji-Yang
中科院分区：
文献类型：
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作者：
Wang，Ying;Liu，Jun;Wang，Ji-Yang
自1965年发现B细胞以来(Cooper et al.1965)，三年来，我们对B细胞的发育、成熟和功能的认识有了巨大的进步。已鉴定出许多B细胞亚群，包括B-1、B-2和调节性B细胞。B-1细胞主要来源于胎肝，含有B-1a和B-1b亚群。B-2细胞来源于骨髓，可进一步分为滤泡B细胞(FOB)和边缘带B细胞(MZB)。调节B细胞(Bregs)主要通过产生抗炎细胞因子IL-10来抑制免疫反应。B细胞耐受性是在几个检查点上建立的，在B细胞发育期间(中枢耐受)以及在B细胞成熟和外周激活期间(外周耐受)。本章将集中于B-1和B-2细胞发育和成熟过程中的重要过程的调节。
Since the identification of B cells in 1965 (Cooper et al. 1965), three has been tremendous progress in our understanding of B cell development, maturation and function. A number of B cell subpopulations, including B-1, B-2 and regulatory B cells, have been identified. B-1 cells mainly originate from the fetal liver and contain B-1a and B-1b subsets. B-2 cells are derived from the bone marrow (BM) and can be further classified into follicular B (FOB) and marginal zone B (MZB) cells. Regulatory B cells (Bregs) function to suppress immune responses, primarily by production of the anti-inflammatory cytokine IL-10. B cell tolerance is established at several checkpoints, during B cell development in the BM (central tolerance) as well as during B cell maturation and activation in the periphery (peripheral tolerance). This chapter will focus on the regulation of important processes during the development and maturation of B-1 and B-2 cells.