ENTORHINAL NEUROFIBRILLARY TANGLES IN ALZHEIMER-DISEASE WITH LEWY BODIES
ENTORHINAL NEUROFIBRILLARY TANGLES IN ALZHEIMER-DISEASE WITH LEWY BODIES
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DOI：
10.1016/0304-3940(91)90478-c
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发表时间：
1991-08-19
影响因子：
2.5
通讯作者：
REXIN, D
中科院分区：
文献类型：
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作者：
HANSEN, LA;MASLIAH, E;REXIN, D
内嗅皮层是海马区传入神经的主要来源。它的神经元，特别是在第二层，在阿尔茨海默病(AD)中形成神经原纤维缠结(NFT)。我们量化了AD患者、老年对照组和同时患有AD病理以及皮质下和新皮质路易小体(A路易小体变体，LBV)的大脑中的内嗅觉NFT。病因学上的争议在于LBV是AD的一种形式还是另一种疾病，因为它们的新皮质NFT很少，而且它们的神经斑通常缺乏成对的螺旋细丝免疫反应性。LBV的内脏NFT比对照组多(P<；0.001)，但比ADS少(P<；0.02)，尽管有类似数量的神经炎斑块。LBVS的AD病理为中度严重，或可能处于早期发育阶段。
Entorhinal cortex is the major source of hippocampal afferents. Its neurons, especially in layer 2, develop neurofibrillary tangles (NFTs) in Alzheimer disease (AD). We quantified entorhinal NFTs in cases of AD, elderly controls, and in brains with both AD pathology and subcortical and neocortical Lewy bodies, (a Lewy body variant, LBV). A nosologic controversy hinges on whether LBVs are a form of AD or a different disease, since they have few neocortical NFTs and their neuritic plaques often lack paired helical filament immunoreactivity. The LBVs had more entorhinal NFTs than controls (P < 0.001), but fewer than ADs (P < 0.02), despite comparable numbers of neuritic plaques. AD pathology in LBVs is of moderate severity, or perhaps in an earlier developmental stage.