Muscle volume is related to trabecular and cortical bone architecture in typically developing children
Muscle volume is related to trabecular and cortical bone architecture in typically developing children
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DOI：
10.1016/j.bone.2015.07.014
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发表时间：
2015-12-01
期刊：
影响因子：
4.1
通讯作者：
Modlesky, Christopher M.
中科院分区：
文献类型：
--
作者：
Bajaj, Deepti;Allerton, Brianne M.;Modlesky, Christopher M.
简介：肌肉与儿童的皮质骨结构密切相关；然而，肌肉体积和骨小梁结构之间的关系研究很少。本研究的目的是确定儿童肌肉体积是否与骨小梁结构相关，以及这种关系是否不同于肌肉体积与皮质骨结构之间的关系。 材料和方法：该研究包括 40 名正常发育的儿童（20 名男孩和 20 名女孩；6 至 12 岁）。测量股骨远端的小梁骨结构 [即表观小梁骨体积与总体积 (appBV/TV)、小梁数量 (appTb.N)、小梁厚度 (appTb.Th) 和小梁间距 (appTb.Sp)]、股骨中段、肌肉的皮质博德结构 [皮质体积、总体积、截面模数 (Z) 和极惯性矩 (J)]使用磁共振成像评估大腿中部的体积和股骨长度。使用佩戴在腰部的基于加速度计的活动监测器为期四天来评估总体身体活动和中度至剧烈的身体活动。使用饮食记录评估钙摄入量。使用多元线性回归分析测试测量值之间的关系。结果：肌肉体积与骨小梁结构测量值存在中度至强相关性 [appBV/TV (r = 0.81)、appTb.N (r = 0.53)、appTb.Th (r = 0.67)、appTb.Sp (r = 0.71)；所有 p < 0.001]，但与皮质骨结构的测量密切相关[皮质体积 (r = 0.96)、总体积 (r = 0.94)、Z (r = 0.94) 和] (r = 0.92；所有 p < 0.001)]。在股骨长度与小梁骨 (p < 0.01) 和皮质 (p < 0.001) 骨结构测量之间也观察到类似的关系。性别、体力活动和钙摄入量与任何骨结构测量均无关（p > 0.05）。由于肌肉体积和股骨长度密切相关（r = 0.91，p < 0.001），因此肌肉体积根据股骨长度进行缩放（肌肉体积/股骨长度(2.77)）。当肌肉体积/股骨长度 (2.77) 包含在股骨长度、性别、体力活动和钙摄入量的回归模型中时，肌肉体积/股骨长度 (2.77) 是 appBV/TV、appTb.Th 和 appTb.Sp（部分 r = 0.44 至 0.49，p < 0.05）和所有皮质骨结构测量（部分 r = 0.47 至0.54；p < 0.01）。结论：研究结果表明，大腿中部的肌肉体积与典型发育儿童股骨远端的骨小梁结构有关。这种关系弱于大腿中部肌肉体积与股骨中部皮质骨结构之间的关系，但这种差异在很大程度上是由皮质骨结构测量对股骨长度的更大依赖性造成的。 (C) 2015 Elsevier Inc. 保留所有权利。
Introduction: Muscle is strongly related to cortical bone architecture in children; however, the relationship between muscle volume and trabecular bone architecture is poorly studied. The aim of this study was to determine if muscle volume is related to trabecular bone architecture in children and if the relationship is different than the relationship between muscle volume and cortical bone architecture.Materials and methods: Forty typically developing children (20 boys and 20 girls; 6 to 12 y) were included in the study. Measures of trabecular bone architecture [i.e., apparent trabecular bone volume to total volume (appBV/TV), trabecular number (appTb.N), trabecular thickness (appTb.Th) and trabecular separation (appTb.Sp)] in the distal femur, cortical bode architecture [cortical volume, total volume, section modulus (Z) and polar moment of inertia (J)] in the midfemur, muscle volume in the midthigh and femur length were assessed using magnetic resonance imaging. Total physical activity and moderate-to-vigorous physical activity were assessed using an accelerometer-based activity monitor worn around the waist for four days. Calcium intake was assessed using diet records. Relationships among the measures were tested using multiple linear regression analysis.Results: Muscle volume was moderately-to-strongly related to measures of trabecular bone architecture [appBV/TV (r = 0.81), appTb.N (r = 0.53), appTb.Th (r = 0.67), appTb.Sp (r = 0.71.); all p < 0.001] but more strongly related to measures of cortical bone architecture [cortical volume (r = 0.96), total volume (r = 0.94),Z (r = 0.94) and.] (r = 0.92; all p < 0.001)]. Similar relationships were observed between femur length and measures of trabecular (p < 0.01) and cortical (p < 0.001) bone architecture. Sex, physical activity and calcium intake were not related to any measure of bone architecture (p > 0.05). Because muscle volume and femur length were strongly related (r = 0.91, p < 0.001), muscle volume was scaled for femur length (muscle volume/femur length(2.77)). When muscle volume/femur length(2.77) was included in a regression model with femur length, sex, physical activity and calcium intake, muscle volume/femur length(2.77) was a significant predictor of appBV/TV, appTb.Th and appTb.Sp (partial r = 0.44 to 0.49, p < 0.05) and all measures of cortical bone architecture (partial r = 0.47 to 0.54; p < 0.01).Conclusions: The findings suggest that muscle volume in the midthigh is related to trabecular bone architecture in the distal femur of typically developing children. The relationship is weaker than the relationship between muscle volume in the midthigh and cortical bone architecture in the midfemur, but the discrepancy is driven, in large part, by the greater dependence of cortical bone architecture measures on femur length. (C) 2015 Elsevier Inc. All rights reserved.