QUANTITATIVE STUDY OF CELL-PROLIFERATION IN EPENDYMA AND CHOROID-PLEXUS IN THE POSTNATAL RAT-BRAIN
QUANTITATIVE STUDY OF CELL-PROLIFERATION IN EPENDYMA AND CHOROID-PLEXUS IN THE POSTNATAL RAT-BRAIN
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DOI：
10.1111/j.1365-2990.1979.tb00629.x
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发表时间：
1979-01-01
影响因子：
5
通讯作者：
LEWIS, PD
中科院分区：
文献类型：
--
作者：
CHAUHAN, AN;LEWIS, PD
用放射自显影技术研究了大鼠前脑室管膜和脉络丛上皮细胞在注射[~3H]-胸腺嘧啶核苷后的增殖活性。侧脑室的标记指数高于第三脑室，脉络丛上皮的标记指数低于室管膜。在所有被检查的区域中，标记指数在出生后头两周显示出类似的下降模式，到第12天时达到约第1天的20-30%的水平。这一低水平对应于室管膜130天的周转时间，此后一直维持到第42天，表明幼年成虫的增殖持续。
Proliferative activity in forebrain ependyma and choroid plexus epithelium was studied in rats aged up to 42 days by autoradiography after injection of [3H]-thymidine. Labeling indices were higher in the lateral than in the 3rd ventricle, while values for choroid plexus epithelium were lower than those for ependyma. In all areas examined, labeling indices showed a similar pattern of decline in the first 2 postnatal weeks reaching by day 12 a level about 20-30% of that on day 1. This low level, corresponding to a turnover time of 130 days for ependyma, was maintained thereafter up to day 42, indicating the persistence of proliferation in the young adult.