An investigation of risk factors for renal cell carcinoma by histologic subtype in two case-control studies.
An investigation of risk factors for renal cell carcinoma by histologic subtype in two case-control studies.
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DOI：
10.1002/ijc.27934
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发表时间：
2013-06-01
影响因子：
6.4
通讯作者：
Chow, Wong-Ho
中科院分区：
文献类型：
--
作者：
Purdue, Mark P.;Moore, Lee E.;Merino, Maria J.;Boffetta, Paolo;Colt, Joanne S.;Schwartz, Kendra L.;Bencko, Vladimir;Davis, Faith G.;Graubard, Barry I.;Janout, Vladimir;Ruterbusch, Julie J.;Beebe-Dimmer, Jennifer;Cote, Michele L.;Shuch, Brian;Mates, Dana;Hofmann, Jonathan N.;Foretova, Lenka;Rothman, Nathaniel;Szeszenia-Dabrowska, Neonilia;Matveev, Vsevolod;Wacholder, Sholom;Zaridze, David;Linehan, W. Marston;Brennan, Paul;Chow, Wong-Ho
为了研究肾细胞癌（RCC）的组织学亚型是否具有不同的病因，我们在美国（1，217例，1，235例对照）和欧洲（1，097例，1，476例对照）进行的两项病例对照研究中，通过亚型（透明细胞，乳头状细胞，嫌色细胞）分析了确定的RCC风险因素。通过由一名病理学家进行的中央切片审查，确定了706例美国病例（占总数的58%）和917例欧洲病例（84%）的组织学。对于其余病例，从原始诊断病理学报告中提取组织学。仅进行病例分析，以计算比值比（OR）和95%置信区间（CI），按年龄、性别和种族总结亚型差异。采用多分类回归进行病例对照分析，计算其他危险因素的亚型特异性OR。在仅病例分析中，与透明细胞病例（N= 1，524）相比，乳头状病例（N=237）年龄更大（OR=1.2，95% CI=1.1-1.4/10年增加），女性的可能性更小（OR=0.5，95% CI=0.4- 0.8），黑人的可能性更大（OR=2.6，95% CI=1.8-3.9）。在病例对照分析中，BMI与透明细胞（OR=1.2，95%CI =1.1-1.3/5 kg/m2增加）和嫌色细胞RCC（N=80; OR=1.2，95%CI =1.1- 1.4）相关，但与乳头状RCC无关（OR=1.1，95%CI =1.0-1.2;测试vs.透明细胞，P=0.006）。未观察到与吸烟、高血压或肾癌家族史相关的亚型差异。我们的研究结果支持RCC亚型存在不同的年龄、性别和种族分布，并表明肥胖与RCC的关系因组织学而异。
To investigate whether renal cell carcinoma (RCC) histologic subtypes possess different etiologies, we conducted analyses of established RCC risk factors by subtype (clear cell, papillary, chromophobe) in two case-control studies conducted in the United States (1,217 cases, 1,235 controls) and Europe (1,097 cases, 1,476 controls). Histology was ascertained for 706 U.S. cases (58% of total) and 917 European cases (84%) through a central slide review conducted by a single pathologist. For the remaining cases, histology was abstracted from the original diagnostic pathology report. Case-only analyses were performed to compute odds ratios (ORs) and 95% confidence intervals (CI) summarizing subtype differences by age, sex, and race. Case-control analyses were performed to compute subtype-specific ORs for other risk factors using polytomous regression. In case-only analyses, papillary cases (N=237) were older (OR=1.2, 95% CI=1.1–1.4 per 10-year increase), less likely to be female (OR=0.5, 95 % CI=0.4- 0.8) and more likely to be black (OR=2.6, 95% CI=1.8–3.9) compared to clear cell cases (N=1,524). In case-control analyses, BMI was associated with clear cell (OR=1.2, 95% CI=1.1–1.3 per 5kg/m2 increase) and chromophobe RCC (N=80; OR=1.2, 95% CI=1.1- 1.4), but not papillary RCC (OR=1.1, 95% CI=1.0–1.2; test vs. clear cell, P=0.006). No subtype differences were observed for associations with smoking, hypertension or family history of kidney cancer. Our findings support the existence of distinct age, sex and racial distributions for RCC subtypes, and suggest that the obesity-RCC association differs by histology.
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DOI：
10.1038/nrurol.2010.47
发表时间：
2010-05
期刊：
Nature reviews. Urology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.5
作者：
Lowrance WT;Thompson RH;Yee DS;Kaag M;Donat SM;Russo P
通讯作者：
Russo P
DOI：
10.3109/00365599.2011.579576
发表时间：
2011-11-01
影响因子：
--
作者：
Ingimarsson, Johann P.;Hardarson, Sverrir;Gudbjartsson, Tomas
通讯作者：
Gudbjartsson, Tomas
DOI：
10.1111/j.1467-9876.2010.00731.x
发表时间：
2011-01-01
影响因子：
1.6
作者：
Li, Yan;Graubard, Barry I.;DiGaetano, Ralph
通讯作者：
DiGaetano, Ralph
影响因子：
6.6
作者：
Liu, Hao;Hemminki, Kari;Sundquist, Jan
通讯作者：
Sundquist, Jan