Total Synthesis of Gracilamine
Total Synthesis of Gracilamine
复制标题
江西拉明的全合成
DOI：
10.1002/anie.201405418
复制
发表时间：
2014-09-01
影响因子：
16.6
通讯作者：
Gao, Shuanhu
中科院分区：
文献类型：
--
作者：
Shi, Yingbo;Yang, Baochao;Gao, Shuanhu
The total synthesis of gracilamine, a pentacyclic Amaryllidaceae alkaloid, was achieved from simple building blocks. The synthesis features a mild photo-Nazarov reaction, intramolecular 1,4-addition, and an intramolecular Mannich reaction. This approach not only confirms the C6 stereochemistry of natural gracilamine, and also provides a novel solution to prepare its derivatives and structurally related natural products.
