Stroke risk profile predicts white matter hyperintensity volume - The Framingham Study
Stroke risk profile predicts white matter hyperintensity volume - The Framingham Study
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DOI：
10.1161/01.str.0000135226.53499.85
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发表时间：
2004-08-01
期刊：
影响因子：
8.3
通讯作者：
DeCarli, C
中科院分区：
文献类型：
--
作者：
Jeerakathil, T;Wolf, PA;DeCarli, C
背景和目的--由于未能排除症状性脑血管疾病和痴呆，或者由于使用半定量而非定量方法测量脑白质体积（WMHV），以前对脑MRI上的心血管危险因素和白色高信号（WMH）的研究受到限制。我们研究了中风和痴呆症的Frachial OffspringCohorts.Methods-Brain MRI的Frachial OffspringCohorts.Methods-Brain中风风险档案（FSRP）和WMHV之间的关系进行了定量测量中风和痴呆症的Frachial OffspringCohorts.Methods-Brain MRI的1814名成员。使用半自动算法获得基于像素的头部大小校正WMHV的定量测量。WMHV不呈正态分布，因此进行对数转换（LWMHV）。在MRI前平均7.5年测量的FSRP及其组成风险因素与LWMHV的连续测量和大量LWMHV（LWMHV-大）的存在相关。所有的分析都调整了年龄和sex.Results-FSRP与LWMHV和LWMHV-大。年龄，吸烟，心血管疾病史，高血压，左心室肥厚心电图均显着相关的LWMHV或LWMHV-大。结论FSRP和几个心血管危险因素相关的WMHV连续测量和大容量的WMH的分类名称。这些发现为WMH的血管基础提供了强有力的证据。
Background and Purpose-Previous studies of cardiovascular risk factors and white matter hyperintensity (WMH) on brain MRI have been limited by the failure to exclude symptomatic cerebrovascular disease and dementia or by the use of semiquantitative rather than quantitative methods to measure WMH volume (WMHV). We examined the relationship between Framingham Stroke Risk Profile (FSRP) and WMHV measured quantitatively in a stroke and dementia-free subset of the Framingham Offspring Cohort.Methods-Brain MRI was performed in 1814 members of the Framingham Offspring Cohort. Pixel-based quantitative measures of WMHV corrected for head size were obtained using a semiautomated algorithm. WMHV was not normally distributed and therefore was log-transformed (LWMHV). The FSRP and its component risk factors measured a mean of 7.5 years before MRI were related to both continuous measures of LWMHV and to the presence of large volumes of LWMHV (LWMHV-large). All analyses were adjusted for age and sex.Results-FSRP was strongly associated with LWMHV and LWMHV-large. Age, smoking, history of cardiovascular disease, hypertension, and left ventricular hypertrophy by electrocardiogram were all significantly related to LWMHV or LWMHV-large.Conclusions-FSRP and several cardiovascular risk factors were related to both WMHV measured continuously and to a categorical designation of large volumes of WMH. These findings provide strong evidence of a vascular basis for WMH.