One-Pot Transformation of Me3Si-/Ph2P(O)-Protected Ethynes to Unsymmetrical Arylethynes

One-Pot Transformation of Me3Si-/Ph2P(O)-Protected Ethynes to Unsymmetrical Arylethynes
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DOI：
10.3184/174751918x15269925671284
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发表时间：
2018-05
期刊：
Journal of Chemical Research
影响因子：
1.4
通讯作者：
Li-fen Peng;J. Lei;L. Wu;Zi-long Tang;Zhi Luo;Y. Jiao;Xinhua Xu
Li-fen Peng;J. Lei;L. Wu;Zi-long Tang;Zhi Luo;Y. Jiao;Xinhua Xu
中科院分区：
化学4区
文献类型：
--
作者：
Li-fen Peng;J. Lei;L. Wu;Zi-long Tang;Zhi Luo;Y. Jiao;Xinhua Xu

文献摘要

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通过Ph2P(O)-脱保护/ [Pd(dppf)Cl2]催化偶联和Me3Si-脱保护/Sonogashira偶联，在温和高产率条件下成功地将Me3Si-/Ph2P(O)保护乙烯转化为不对称芳基乙烯。成功合成了不对称苯乙炔、不对称延伸苯乙炔和不对称蒽乙炔。
Me3Si-/Ph2P(O)-protected ethynes were successfully transformed to unsymmetrical arylethynes via a one-pot Ph2P(O)-deprotection/ [Pd(dppf)Cl2]-catalysed coupling and one-pot Me3Si-deprotection/Sonogashira coupling under mild conditions and in high yield. Unsymmetrical phenylethynes, unsymmetrical extended phenylene ethynylenes and unsymmetrical anthrylethynes were successfully synthesised in good to excellent yields.