The post-translational modification of Fascin: impact on cell biology and its associations with inhibiting tumor metastasis
The post-translational modification of Fascin: impact on cell biology and its associations with inhibiting tumor metastasis
复制标题
DOI：
10.1007/s00726-022-03193-x
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Enmin Li
中科院分区：
文献类型：
--
作者：
Nan-Li;Zhi-Da Zhang;Rong-Rong Li;Jia-You Chen;Hong-Xin Huang;Yin-Wei Cheng;Liyan Xu;Enmin Li
The post-translational modifications (PTMs), which are crucial in the regulation of protein functions, have great potential as biomarkers of cancer status. Fascin (Fascin actin-bundling protein 1, FSCN1), a key protein in the formation of filopodia that is structurally based on actin filaments (F-actin), is significantly associated with tumor invasion and metastasis. Studies have revealed various regulatory mechanisms of human Fascin, including PTMs. Although a number of Fascin PTM sites have been identified, their exact functions and clinical significance are much less explored. This review explores studies on the functions of Fascin and briefly discusses the regulatory mechanisms of Fascin. Next, to review the role of Fascin PTMs in cell biology and their associations with metastatic disease, we discuss the advances in the characterization of Fascin PTMs, including phosphorylation, ubiquitination, sumoylation, and acetylation, and the main regulatory mechanisms are discussed. Fascin PTMs may be potential targets for therapy for metastatic disease.
