A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force.
A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force.
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DOI：
10.1002/epi4.12260
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发表时间：
2018-11
期刊：
影响因子：
3
通讯作者：
Galanopoulou AS
中科院分区：
文献类型：
--
作者：
Ono T;Wagenaar J;Giorgi FS;Fabera P;Hanaya R;Jefferys J;Moyer JT;Harte-Hargrove LC;Galanopoulou AS
脑电图（EEG）通常用于癫痫和神经科学研究，以研究大脑活动。EEG记录的原理，如信号采集、数字化和调节，在动物和临床EEG系统之间具有相似性。相比之下，临床前EEG研究在EEG电极的类型和位置、数据分析方法以及EEG模式和相关行为的评分方面表现出比临床研究更多的可变性和多样性。国际抗癫痫联盟/美国癫痫学会（ILAE/AES）联合翻译工作组的TASK 3 EEG工作组开发了一套临床前通用数据元素（CDE）和病例报告表（CRF），用于动物EEG研究的记录、分析和评分。本随附文件随附了第一组拟定临床前EEG CRF，旨在阐明这些CRF中包含的CDE。我们提供了7个CRF和随附的CDE模块供研究团体使用，包括视频采集、电极信息、实验安排和EEG活动评分。为便于使用，所有数据元素和输入范围均在支持性Excel图表中定义（附录S1）。
Electroencephalography (EEG) is commonly used in epilepsy and neuroscience research to study brain activity. The principles of EEG recording such as signal acquisition, digitization, and conditioning share similarities between animal and clinical EEG systems. In contrast, preclinical EEG studies demonstrate more variability and diversity than clinical studies in the types and locations of EEG electrodes, methods of data analysis, and scoring of EEG patterns and associated behaviors. The TASK3 EEG working group of the International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force has developed a set of preclinical common data elements (CDEs) and case report forms (CRFs) for recording, analysis, and scoring of animal EEG studies. This companion document accompanies the first set of proposed preclinical EEG CRFs and is intended to clarify the CDEs included in these worksheets. We provide 7 CRF and accompanying CDE modules for use by the research community, covering video acquisition, electrode information, experimental scheduling, and scoring of EEG activity. For ease of use, all data elements and input ranges are defined in supporting Excel charts (Appendix S1).