PHARMACOLOGICAL EVIDENCE FOR SYNAPTIC TRANSMISSION MEDIATED BY NON-N-METHYL-D-ASPARTATE RECEPTORS IN THE AVIAN COCHLEAR NUCLEUS
PHARMACOLOGICAL EVIDENCE FOR SYNAPTIC TRANSMISSION MEDIATED BY NON-N-METHYL-D-ASPARTATE RECEPTORS IN THE AVIAN COCHLEAR NUCLEUS
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DOI：
10.1016/0304-3940(83)90089-7
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发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
PARKS, TN
中科院分区：
文献类型：
--
作者：
NEMETH, EF;JACKSON, H;PARKS, TN
Synaptic transmission between the auditory nerve and the cochlear nucleus mediated by an excitatory amino acid acting through N-methyl-D-aspartate (NMDA) receptors was examined in an in vitro preparation of the chicken brainstem. The ability of various bath-applied excitatory amino acid receptor antagonists to inhibit synaptically-evoked responses was assessed by recording field potentials from nucleus magnocellularis (NM) following electrical stimulation of the cochlear nerve. Antagonists that selectively block responses mediated by NMDA receptors, such as D-.alpha.-aminoadipate and 2-amino-5-phosphonovalerate, were without effect on evoked transmission in NM. Antagonists that additionally act on non-NMDA receptors, such as cis-2,3-piperidine dicarboxylate and .gamma.-D-glutamylglycine, reversibly suppressed transmission. Evidently, transmission in the chicken auditory system is mediated by non-NMDA receptors; and a substance(s) chemically akin to aspartate and glutamate may be the transmitter used by the auditory nerve in NM.
