Heterogeneity of reactive astrocytes.
Heterogeneity of reactive astrocytes.
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DOI：
10.1016/j.neulet.2013.12.030
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发表时间：
2014-04-17
影响因子：
2.5
通讯作者：
Sofroniew MV
中科院分区：
文献类型：
--
作者：
Anderson MA;Ao Y;Sofroniew MV
Astrocytes respond to injury and disease in the central nervous system (CNS) with a process referred to as reactive astrogliosis. Recent progress demonstrates that reactive astrogliosis is not a simple all-or-none phenomenon, but is a finely gradated continuum of changes that range from reversible alterations in gene expression and cell hypertrophy, to scar formation with permanent tissue rearrangement. There is now compelling evidence that reactive astrocytes exhibit a substantial potential for heterogeneity at multiple levels, including gene expression, cell morphology, topography (distance from lesions), CNS regions, local (among neighboring cells), cell signaling and cell function. Structural and functional changes are regulated in reactive astrocytes by many different potential signaling events that occur in a context dependent manner. It is noteworthy that different stimuli of astrocyte reactivity can lead to similar degrees of GFAP upregulation while causing substantially different changes in transcriptome profiles and cell function. Thus, it is not possible to equate simple and uniform measures such as cell hypertrophy and upregulation of GFAP expression with a single, uniform concept of astrocyte reactivity. Instead, it is necessary to recognize the considerable potential for heterogeneity and determine the functional implications of astrocyte reactivity in a context specific manner as regulated by specific signaling events.
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影响因子：
34.7
作者：
Clarke, Laura E.;Barres, Ben A.
通讯作者：
Barres, Ben A.
影响因子：
15.3
作者：
Brambilla, R;Bracchi-Ricard, V;Hu, WH;Frydel, B;Bramwell, A;Karmally, S;Green, EJ;Bethea, JR
通讯作者：
Bethea, JR
影响因子：
6.2
作者：
Imura, T;Nakano, I;Sofroniew, MV
通讯作者：
Sofroniew, MV
DOI：
10.1523/jneurosci.1256-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hamby ME;Coppola G;Ao Y;Geschwind DH;Khakh BS;Sofroniew MV
通讯作者：
Sofroniew MV
DOI：
10.4049/jimmunol.0802954
发表时间：
2009-03-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brambilla R;Persaud T;Hu X;Karmally S;Shestopalov VI;Dvoriantchikova G;Ivanov D;Nathanson L;Barnum SR;Bethea JR
通讯作者：
Bethea JR