Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation.
Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation.
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DOI：
10.1017/s1462399409000957
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发表时间：
2009-01-20
影响因子：
6.2
通讯作者：
Griffin-Thomas L
中科院分区：
文献类型：
--
作者：
Cabral GA;Griffin-Thomas L
现在有大量的数据表明，CB2大麻素受体2型（CB2）与各种免疫功能事件有关。这种功能相关性似乎在炎症过程中最为突出，在此过程中，可用于激活的受体数量增加。旨在阐明CB2与其天然配体相互作用引起的信号转导事件以及外源性大麻素在调节该过程中的作用的研究，为CB2在维持宿主内稳态免疫平衡中的作用提供了新的见解。此外，这些研究表明，CB2可以作为一个选择性的分子靶点，用于治疗操纵不良的免疫反应，包括那些与各种神经病变，表现出高度炎症的组成部分。
There is now a large body of data that indicates that the CB2 cannabinoid receptor type 2 (CB2) is linked to a variety of immune functional events. This functional relevance appears to be most salient in the course of inflammation, a process during which there is an increased number of receptors that are available for activation. Studies aimed at elucidating signal transductional events resulting from CB2 interaction with its native ligands, and of the role of exogenous cannabinoids in modulating this process, are providing novel insights into the role of the CB2 in maintaining a homeostatic immune balance within the host. Furthermore, these studies suggest that the CB2 may serve as a selective molecular target for therapeutic manipulation of untoward immune responses including those associated with a variety of neuropathies that exhibit a hyperinflammatory component.