A classification based on tumor-stroma ratio and tumor budding for patients with muscle-invasive bladder cancer
A classification based on tumor-stroma ratio and tumor budding for patients with muscle-invasive bladder cancer
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基于肿瘤间质比和肿瘤出芽的肌层浸润性膀胱癌患者分类
DOI：
10.1080/14737140.2022.2012158
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发表时间：
2021-12-10
影响因子：
3.3
通讯作者：
Song, Xishuang
中科院分区：
文献类型：
--
作者：
Liu, Junqiang;Li, Chun;Song, Xishuang
背景肿瘤间质比（TSR）和肿瘤出芽（TB）在肌层浸润性膀胱癌（MIBC）中起重要作用。我们开发了一个评级系统（TSR-TB型）的基础上的TSR和TB的形态学评价预测患者的结果和使用个性化的护理。方法在TCGA数据库中公开访问的MIBC肿瘤切片中评估TSR和TB。根据TSR将MIBC患者分为低基质型或高基质型，根据TB将高基质型进一步分为间室化或混合基质型。结果TSR-TB型是影响OS的独立预后因素（P < 0.001）。低基质型预后更好（P < 0.001），且富含FGFR 3突变（P = 0.001）。混合基质型的特点是M2巨噬细胞渗透增加（P < 0.001），抗肿瘤免疫活性，DNA修复途径突变，生存率低。GSEA显示，在高基质型（均为FDR）中，某些与癌症相关的通路，如有丝分裂纺锤体、PI 3 K-AKT-MTOR信号通路被过度激活
Background Tumor-stroma ratio (TSR) and tumor budding (TB) play important roles in muscle-invasive bladder cancer (MIBC). We developed a rating system (TSR-TB type) based on the morphological evaluation of TSR and TB for predicting patient outcome and using individualized care. Methods TSR and TB were assessed in publicly accessible MIBC tumor slides from the TCGA database. MIBC patients were classified as low stromal or high stromal type based on TSR, and high stromal type was further classified as compartmentalized or mixed stromal type based on TB. Results TSR-TB type was an independent adverse prognostic factor for OS (P < 0.001). Low stromal type had a greater prognosis (P < 0.001) and were enriched for FGFR3 mutations (P = 0.001). The mixed stromal type was distinguished by increased M2 macrophage penetration (P < 0.001), anti-tumor immune activity, DNA repair pathway mutations, and poor survival. GSEA showed that certain cancer-related pathways, such as mitotic spindle, PI3K-AKT-MTOR signalingwere hyperactivated in high stromal type (all FDR