Estimating age-specific incidence of dementia using prevalent cohort data.
Estimating age-specific incidence of dementia using prevalent cohort data.
复制标题
使用流行的队列数据估计特定年龄的痴呆症发病率。
DOI：
10.1080/00949650903583496
复制
发表时间：
2011
影响因子：
1.2
通讯作者：
Yu,Binbing
中科院分区：
文献类型：
--
作者：
Yu,Binbing
在前瞻性队列研究中，通常根据一定的横断面抽样标准招募个体。流行队列被定义为在研究开始时还活着但可能患有疾病的一组个体。在入组前结合流行病例估计疾病发生率是有吸引力的。本文应用发病率反算的方法估计人类免疫缺陷病毒（HIV）感染到艾滋病（AIDS）的潜伏期。时间起点定义为感染艾滋病毒的时间。在老龄化队列研究中，主要时间尺度是疾病发作的年龄，受试者必须存活一定年才能入组研究，因此产生左截断（延迟入组）。目前的方法通常假设疾病的发病率是罕见的，或者与健康受试者相比，由于疾病导致的超额死亡率很小。到目前为止，基于这些假设的结果的有效性还没有得到检验。本文提出了一种简单的替代方法，估计痴呆发病率在入学前使用流行队列数据与左截断。此外，模拟被用来检查的疾病发病率和超额死亡率的风险，由于疾病的不同假设下的疾病发病率的估计的性能。作为应用，该方法适用于流行的情况下，痴呆的檀香山-亚洲老龄化研究，估计痴呆的发病率，并评估高血压，载脂蛋白4和教育对痴呆发作的影响。
In prospective cohort studies, individuals are usually recruited according to a certain cross-sectional sampling criterion. The prevalent cohort is defined as a group of individuals who are alive but possibly with disease at the beginning of the study. It is appealing to incorporate the prevalent cases to estimate the incidence rate of disease before the enrollment. The method of back calculation of incidence rate has been used to estimate the incubation time from human immunodeficiency virus (HIV) infection to AIDS. The time origin is defined as the time of HIV infection. In aging cohort studies, the primary time scale is age of disease onset, subjects have to survive certain years to be enrolled into the study, thus creating left truncation (delay entry). The current methods usually assume that either the disease incidence is rare or the excess mortality due to disease is small compared with the healthy subjects. So far the validity of the results based on these assumptions has not been examined. In this paper, a simple alternative method is proposed to estimate dementia incidence rate before enrollment using prevalent cohort data with left truncation. Furthermore, simulations are used to examine the performance of the estimation of disease incidence under different assumptions of disease incidence rates and excess mortality hazards due to disease. As application, the method is applied to the prevalent cases of dementia from the Honolulu-Asia Aging Study to estimate the dementia incidence rate and to assess the effect of hypertension, Apoe 4 and education on dementia onset.