Muscle cell type diversification facilitated by extensive gene duplications
Muscle cell type diversification facilitated by extensive gene duplications
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广泛的基因重复促进了肌肉细胞类型多样化
DOI：
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
U. Technau
中科院分区：
文献类型：
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作者：
A. Cole;Sabrina Kaul;Stefan M. Jahnel;Julia Steger;Bob Zimmerman;R. Reischl;G. Richards;Fabian Rentzsch;Patrick R. H. Steinmetz;U. Technau
新细胞类型出现的进化机制仍不清楚。在这里，我们研究了双胚层海葵 Nematostella vectensis 肌肉细胞的起源和多样化。我们在 Nematostella 中辨别出两个快速收缩的肌肉细胞群和两个慢速收缩的肌肉细胞群，其差异在于广泛的旁系同源基因组。慢速刺胞动物肌肉和两侧对称动物心肌的调节基因组非常相似。相比之下，这两种快速肌肉彼此有很大不同，同时驱动相同的旁系同源结构蛋白基因。我们的数据表明，广泛的基因重复和个体效应模块的共同选择可能在后生动物进化过程中的细胞类型多样化中发挥了重要作用。一句话总结 对简单海葵的研究提出了细胞类型进化和形态复杂性的分子机制。
The evolutionary mechanisms underlying the emergence of new cell types are still unclear. Here, we address the origin and diversification of muscle cells in the diploblastic sea anemone Nematostella vectensis. We discern two fast and two slow-contracting muscle cell populations in Nematostella differing by extensive sets of paralogous genes. The regulatory gene set of the slow cnidarian muscles and the bilaterian cardiac muscle are remarkably similar. By contrast, the two fast muscles differ substantially from each other, while driving the same set of paralogous structural protein genes. Our data suggest that extensive gene duplications and co-option of individual effector modules may have played an important role in cell type diversification during metazoan evolution. One Sentence Summary The study of the simple sea anemone suggests a molecular mechanism for cell type evolution and morphological complexity.