d-limonene mechanistic data and risk assessment: absolute species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion.
d-limonene mechanistic data and risk assessment: absolute species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion.
复制标题
d-柠檬烯机制数据和风险评估：绝对物种特异性细胞毒性、增强细胞增殖和促进肿瘤。
DOI：
10.1016/0163-7258(96)00065-4
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发表时间：
1996
影响因子：
13.5
通讯作者：
Williams,GM
中科院分区：
文献类型：
--
作者：
Whysner,J;Williams,GM
d-Limonene produces tumors only in the kidneys of male rats in association with hyaline-droplet nephropathy, which is due to the accumulation of the rat-specific, low molecular weight protein α2u-globulin in the P2 segment cells of renal proximal tubules. Human urine contains no α2u-globulin and, compared with the male rat, much less protein and almost no low molecular weight protein. Genotoxicity tests for d-limonene are negative, and the mechanism of tumorigenesis involves tumor promotion and enhanced cell proliferation. There is no risk of cancer for humans from d-limonene, since the binding of d-limonene to α2u-globulin would not occur.
