Chronic hepatitis C virus infection and increases in viral load in a prospective cohort of young, HIV-uninfected injection drug users
Chronic hepatitis C virus infection and increases in viral load in a prospective cohort of young, HIV-uninfected injection drug users
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DOI：
10.1016/j.drugalcdep.2011.06.005
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发表时间：
2011-12-15
影响因子：
4.2
通讯作者：
Ouellet, Lawrence J.
中科院分区：
文献类型：
--
作者：
Boodram, Basrnattee;Hershow, Ronald C.;Ouellet, Lawrence J.
背景：慢性丙型肝炎 (HCV) 感染，定义为持续至少 6 个月的持续 RNA（病毒载量），占所有肝硬化、终末期肝病和肝癌病例的 50%。此外，HCV 病毒载量升高始终与高传染性和不良治疗反应相关。本研究旨在确定注射吸毒者 (IDU) 中慢性 HCV 感染和病毒载量随时间增加的可改变行为相关性。方法：使用来自美国伊利诺伊州芝加哥市的年轻人（18-35 岁）、HIV 阴性、未接受过 HCV 治疗的 IDU（n = 113）的自我访谈和前瞻性队列研究（2002-2006）的血清学数据进行横断面和纵向分析。结果：调整后对于年龄、性别和种族/民族，使用在他人注射器中测量或混合的药物（比值比 = 2.7，95% 置信区间：1.1, 6.7）与慢性 (n = 75.66%) 与解决 (n = 38, 34%) HCV 感染状态相关。在慢性感染的注射吸毒者中，很少使用新的无菌注射器进行注射（
Background: Chronic hepatitis C (HCV) infection, defined as persistent RNA (viral load) for at least 6 months, accounts for up to 50% of all cirrhosis, end-stage liver disease and liver cancer cases. Moreover, elevated HCV viral load is consistently associated with high infectivity and poor therapy response. This study aims to identify modifiable behavioral correlates both chronic HCV infection and increases in viral load over time among injection drug users (IDUs).Methods: Cross-sectional and longitudinal analyses were performed using self-interview and serological data from a prospective cohort study (2002-2006) among young (age 18-35), HIV-negative, HCV therapy-naive IDUs (n = 113) from metropolitan Chicago, Illinois, USA.Results: After adjustment for age, gender and race/ethnicity, using drugs measured or mixed in someone else's syringe (odds ratio = 2.7, 95% confidence interval: 1.1, 6.7) was associated with chronic (n = 75.66%) versus resolved (n = 38, 34%) HCV infection status. Among chronically-infected IDUs, injecting with a new, sterile syringe infrequently (