LNG-IUS 12: a 19.5 levonorgestrel-releasing intrauterine system for prevention of pregnancy for up to five years
LNG-IUS 12: a 19.5 levonorgestrel-releasing intrauterine system for prevention of pregnancy for up to five years
复制标题
DOI：
10.1080/17425247.2017.1353972
复制
发表时间：
2017-01-01
影响因子：
6.6
通讯作者：
Nelson, Anita L.
中科院分区：
文献类型：
--
作者：
Nelson, Anita L.
简介：在全球范围内，宫内节育器 (IUD) 因其高效、安全、方便和成本效益而成为第二常用的可逆避孕形式。每日平均释放量为 20 微克的左炔诺孕酮宫内缓释系统 (LNG-IUS 20) 因其良好的出血模式和许多非避孕益处而成为流行的选择。三年期（LNG-IUS 8）于三年前上市。最近，添加了 LNG-IUS 12。这种新型 IUD 与 LNG-IUS 8 具有较小的框架、较窄的插入器和较低的闭经率，但它提供了 LNG-IUS 20 五年的避孕保护。 涵盖领域：本文基于大约 60,000 个使用周期提供了有关这种新型 IUS 的避孕功效、安全性和耐受性的信息。在可能的情况下，报告了受试者年龄、胎次和体重指数 (BMI) 对研究结果的影响。专家意见：这种新型 LNG-IUS 12 具有中等剂量激素水平、更小的框架和更长的有效寿命，填补了一个空白，可能更好地满足可能欣赏狭窄插入管和/或较低闭经率的女性的需求。成本最终将决定成功。
Introduction: Globally, intrauterine devices (IUDs) are the second most commonly used form of reversible contraception because of their high efficacy, safety, convenience and cost effectiveness. The levonorgestrel releasing intrauterine system with daily average release of 20 mcg (LNG-IUS 20) is the popular choice because of its favorable bleeding patterns and many noncontraceptive benefits. A three year (LNG-IUS 8) became available three years ago. More recently, the LNG-IUS 12 was added. This new IUD shares a smaller frame, narrow inserter and lower rate of amenorrhea with the LNG-IUS 8, but it offers the five years of contraceptive protection of the LNG-IUS 20.Areas covered: This article provides information on the contraceptive efficacy, safety and tolerability of this new IUS based on approximately 60,000 cycles of use. Where available, the impacts of subject age, parity and body mass index (BMI) on study outcomes are reported.Expert opinion: This new LNG-IUS 12 with mid-dose hormone levels, smaller frame and longer effective life fills a niche that may better meet the needs of women who might appreciate the narrow insertion tube and/or the lower rates of amenorrhea. Cost will ultimately help determine success.