EFFECTS OF DROPERIDOL, PENTOBARBITAL, AND KETAMINE ON MYOGENIC TRANSCRANIAL MAGNETIC MOTOR-EVOKED RESPONSES IN HUMANS
EFFECTS OF DROPERIDOL, PENTOBARBITAL, AND KETAMINE ON MYOGENIC TRANSCRANIAL MAGNETIC MOTOR-EVOKED RESPONSES IN HUMANS
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DOI：
10.1227/00006123-199412000-00008
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发表时间：
1994-12-01
期刊：
影响因子：
4.8
通讯作者：
CHESNUT, RM
中科院分区：
文献类型：
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作者：
KALKMAN, CJ;DRUMMOND, JC;CHESNUT, RM
肌源性运动诱发反应经颅磁刺激运动皮层（tc（mag）-MER）可能成为临床上有用的非侵入性评估运动通路传导在手术中。然而，由于大多数麻醉方案导致tc（mag）-MER振幅的严重抑制，因此应用受到阻碍。作为我们系统性尝试确定麻醉剂和补充剂适用于tc（mag）-MER记录的一部分，我们研究了5名健康志愿者静脉注射大剂量戊巴比妥（1.5 mg/kg）、氟哌利多（0.07 mg/kg）或氯胺酮（1 mg/kg）对经颅磁刺激复合肌肉动作电位的影响。选择的剂量应与可能适用于补充一氧化二氮/阿片类麻醉技术的剂量相当。氟哌利多给药导致胫骨肌和拇收肌tc-MER的持续振幅下降至基线的30 +/- 9%和39 +/- 14%（P
MYOGENIC MOTOR-EVOKED RESPONSES to transcranial magnetic stimulation of the motor cortex (tc(mag)-MERs) may become clinically useful for the noninvasive assessment of motor pathway conduction during surgery. However, application is hindered because most anesthetic regimens result in severe depression of tc(mag)-MER amplitudes. As part of our systematic attempts to identify anesthetic agents and supplements suitable for use during tc(mag)-MER recording, we studied the effect of bolus doses of pentobarbital (1.5 mg/kg), droperidol (0.07 mg/kg), or ketamine (1 mg/kg), administered intravenously, on compound muscle action potentials to transcranial magnetic stimulation in five healthy volunteers. The doses were chosen to be comparable with doses that might be suitable for supplementation of a nitrous oxide/opioid anesthetic technique. Droperidol administration resulted in sustained amplitude depression of both tibialis and adductor pollicis tc-MERs to 30 +/- 9% and 39 +/- 14% of baseline (P