Multifaceted role of β-arrestins in inflammation and disease.
Multifaceted role of β-arrestins in inflammation and disease.
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DOI：
10.1038/gene.2015.37
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发表时间：
2015-12
影响因子：
5
通讯作者：
Parameswaran N
中科院分区：
文献类型：
--
作者：
Sharma D;Parameswaran N
抑制蛋白是细胞内支架蛋白，已知可调节一系列生化过程，包括 G 蛋白偶联受体 (GPCR) 脱敏、信号衰减、受体周转和下游信号级联。它们在信号网络调节中的作用最近已扩展到 GPCR 家族以外的受体，证明了它们在增殖、分化和凋亡等各种生理过程中作为重要支架蛋白的作用。最近的研究表明视紫红质抑制蛋白在免疫过程中发挥着关键作用，包括炎症信号通路中的关键功能。在这篇综述中，我们对视紫红质抑制蛋白家族的不同功能进行了全面分析，特别是与免疫和炎症性疾病相关的功能。
Arrestins are intracellular scaffolding proteins known to regulate a range of biochemical processes including G-protein coupled receptor (GPCR) desensitization, signal attenuation, receptor turnover and downstream signaling cascades. Their roles in regulation of signaling network have lately been extended to receptors outside of the GPCR family, demonstrating their roles as important scaffolding proteins in various physiological processes including proliferation, differentiation, and apoptosis. Recent studies have demonstrated a critical role for arrestins in immunological processes including key functions in inflammatory signaling pathways. In this review, we provide a comprehensive analysis of the different functions of the arrestin family of proteins especially related to immunity and inflammatory diseases.