Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line.
Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line.
复制标题
DOI：
10.3389/fmicb.2016.00053
复制
发表时间：
2016
影响因子：
5.2
通讯作者：
Chan KG
中科院分区：
文献类型：
--
作者：
How KY;Song KP;Chan KG
牙周病是由口腔病原体引发的一组口腔炎症感染，这些病原体以复杂的生物膜形式存在于牙齿表面，并对牙齿支持组织造成破坏。这种疾病的严重程度从牙龈的轻度和可逆性炎症（牙龈炎）到结缔组织的慢性破坏、牙周袋的形成并最终导致牙齿脱落。虽然人类龈下菌斑含有 500 多种细菌，但大量研究表明，牙龈卟啉单胞菌（一种革兰氏阴性厌氧菌）是导致慢性牙周炎的主要病原体。这种黑色素细菌产生多种毒力因子，通过调节宿主炎症反应直接或间接破坏牙周组织。在此，本综述概述了牙龈卟啉单胞菌及其毒力因子如何影响口腔中其他微生物组的发病机制。
Periodontal disease represents a group of oral inflammatory infections initiated by oral pathogens which exist as a complex biofilms on the tooth surface and cause destruction to tooth supporting tissues. The severity of this disease ranges from mild and reversible inflammation of the gingiva (gingivitis) to chronic destruction of connective tissues, the formation of periodontal pocket and ultimately result in loss of teeth. While human subgingival plaque harbors more than 500 bacterial species, considerable research has shown that Porphyromonas gingivalis, a Gram-negative anaerobic bacterium, is the major etiologic agent which contributes to chronic periodontitis. This black-pigmented bacterium produces a myriad of virulence factors that cause destruction to periodontal tissues either directly or indirectly by modulating the host inflammatory response. Here, this review provides an overview of P. gingivalis and how its virulence factors contribute to the pathogenesis with other microbiome consortium in oral cavity.