DECREASED SPINAL MINERAL-CONTENT IN AMENORRHEIC WOMEN
DECREASED SPINAL MINERAL-CONTENT IN AMENORRHEIC WOMEN
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DOI：
10.1001/jama.251.5.626
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发表时间：
1984-01-01
影响因子：
120.7
通讯作者：
JAFFE, RB
中科院分区：
文献类型：
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作者：
CANN, CE;MARTIN, MC;JAFFE, RB
绝经前闭经妇女可能有发生骨质疏松症的危险。在高泌乳素血症中，皮质骨质量降低，降低的幅度与雌激素缺乏的严重程度相关。其他原因引起的闭经妇女的骨丢失尚未评估。研究对象为下丘脑性闭经、高泌乳素血症闭经和卵巢早衰的妇女。与年龄匹配的对照组相比，外周皮质骨的骨量仅略有下降，但脊柱骨小梁减少了20- 30%。这些妇女的雌二醇水平为20-80 pg/ml，与正常的早期卵泡水平没有区别。在这些水平下，脊柱骨量的减少与血清雌二醇无关。下丘脑性闭经组由运动员组成，他们的骨量减少是一个意外的发现。
Premenopausal amenorrheic women may be at risk for the development of osteoporosis. In hyperprolactinemia, cortical bone mass is decreased and the magnitude of the decrease correlates with the severity of the estrogen deficiency. Bone loss in women with amenorrhea from other causes has not been assessed. Women with hypothalamic and hyperprolactinemic amenorrhea and premature ovarian failure were studied. Bone mass in the peripheral cortical bone was only slightly decreased from age-matched controls, but spinal trabecular bone was decreased 20-30%. Estradiol levels were 20-80 pg/ml in these women, not different from normal early follicular levels. The decrease in bone mass in the spine did not correlate with serum estradiol at these levels. The hypothalamic amenorrhea group was made up of athletes in whom the bone mass decrease was an unexpected finding.