Year-long Changes in Protein Metabolism in Elderly Men and Women Supplemented With a Nutrition Cocktail of β-Hydroxy-β-methylbutyrate (HMB), L-Arginine, and L-Lysine
Year-long Changes in Protein Metabolism in Elderly Men and Women Supplemented With a Nutrition Cocktail of β-Hydroxy-β-methylbutyrate (HMB), L-Arginine, and L-Lysine
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DOI：
10.1177/0148607108322403
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发表时间：
2009-01-01
影响因子：
3.4
通讯作者：
Flakoll, Paul
中科院分区：
文献类型：
--
作者：
Baier, Shawn;Johannsen, Darcy;Flakoll, Paul
背景：老年人活动能力丧失的一个主要因素是瘦体重的逐渐和持续损失。目的：确定每天补充氨基酸鸡尾酒1年是否可以改善老年人蛋白质周转和瘦体重的年龄相关变化。设计：招募老年（76 +/- 1.6岁）女性（n = 39）和男性（n = 38）进行双盲对照研究。在为期1年的研究中，研究参与者被随机分配到等氮对照补充剂（n = 37）或治疗补充剂（HMB/Arg/Lys），包括β-羟基-β-甲基丁酸酯，L-精氨酸和L-赖氨酸（n = 40）。使用生物电阻抗分析（BIA）和双能X线吸收法（DXA）测量瘦组织质量。全身蛋白质周转率估计使用引发/间歇口服剂量的N-15-甘氨酸。结果如下：在服用HMB/Arg/Lys补充剂的受试者中，瘦肉组织在研究的一年中增加，而在对照组中，瘦肉组织没有变化。与对照组相比，HMB/Arg/Lys使体细胞质量（BIA）增加1.6%（P = .002），瘦体重（DXA）增加1.2%（P = .05）。在3个月和12个月时，补充HMB/Arg/Lys组的蛋白质周转率分别显著增加8%和12%，而对照组的蛋白质周转率分别下降11%和9%（P <0.01）。结论：在一项为期一年的研究中，一种简单的氨基酸相关鸡尾酒的消费增加了老年人的蛋白质周转和瘦肉组织。(JPEN肠外肠内营养杂志2009;33：71-82）
Background: A major contributing factor to the loss of mobility in elderly people is the gradual and continuous loss of lean body mass. Objectives: To determine whether supplementation of an amino acid cocktail daily for 1 year could improve the age-associated changes in protein turnover and lean body mass in elderly people. Design: Elderly (76 +/- 1.6 years) women (n = 39) and men (n = 38) were recruited for a double-blinded controlled study. Study participants were randomly assigned to either an isonitrogenous control-supplement (n = 37) or a treatment-supplement (HMB/Arg/Lys) consisting of beta-hydroxy-beta-methylbutyrate, L-arginine, and L-lysine (n = 40) for the 1-year study. Lean tissue mass was measured using both bioelectrical-impedance analysis (BIA) and dual energy x-ray absorptiometry (DXA). Rates of whole-body protein turnover were estimated using primed/intermittent oral doses of N-15-glycine. Results: In subjects taking the HMB/Arg/Lys supplement, lean tissue increased over the year of study while in the control group, lean tissue did not change. Compared with control, HMB/Arg/Lys increased body cell mass (BIA) by 1.6% (P = .002) and lean mass (DXA) by 1.2% (P = .05). The rates of protein turnover were significantly increased 8% and 12% in the HMB/Arg/Lys-supplemented group while rates of protein turnover decreased 11% and 9% in the control-supplemented subjects (P < .01), at 3 and 12 months, respectively. Conclusions: Consumption of a simple amino acid-related cocktail increased protein turnover and lean tissue in elderly individuals in a year-long study. (JPEN J Parenter Enteral Nutr. 2009;33:71-82)