Sustained treatment-free remission in chronic myeloid leukaemia is associated with an increased frequency of innate CD8(+) T-cells
Sustained treatment-free remission in chronic myeloid leukaemia is associated with an increased frequency of innate CD8(+) T-cells
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DOI：
10.1111/bjh.15858
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发表时间：
2019-07-01
影响因子：
6.5
通讯作者：
Barbarin, Alice
中科院分区：
文献类型：
--
作者：
Cayssials, Emilie;Jacomet, Florence;Barbarin, Alice
慢性粒细胞白血病（CML）免治疗缓解（TFR）的免疫学机制尚不清楚，迄今为止，成功的TFR与CD8（+）T细胞亚群之间没有相关性。我们分析了TFR ≥ 2年的CML患者中一种新发现的人类CD8（+）T细胞亚群，即先天性CD8（+）T细胞。我们证明，与对照组和使用酪氨酸激酶抑制剂缓解的患者相比，这些患者中功能活跃的先天性CD8（+）T细胞显著增加。此外，我们发现先天CD 8（+）T细胞和自然杀伤细胞的频率之间存在正相关性，这可能代表了成功TFR的新先天生物标志物特征。
Immunological mechanisms of treatment-free remission (TFR) in chronic myeloid leukaemia (CML) are poorly defined and, to date, no correlation between successful TFR and CD8(+) T-cell subsets has been found. We analysed a new identified human subset of CD8(+) T-cells, namely innate CD8(+) T-cells, in CML patients with TFR >= 2 years. We demonstrated a dramatic increase of functionally active innate CD8(+) T-cells in these patients as compared to control subjects and patients in remission under tyrosine kinase inhibitors. Moreover, we found a positive correlation between frequencies of innate CD8(+) T-cells and natural killer cells, possibly representing a new innate biomarker profile of successful TFR.