Environmental exposure to cadmium and renal function of elderly women living in cadmium-polluted areas of the Federal Republic of Germany
Environmental exposure to cadmium and renal function of elderly women living in cadmium-polluted areas of the Federal Republic of Germany
复制标题
德意志联邦共和国镉污染地区老年妇女的镉环境暴露与肾功能
DOI：
10.1007/bf00383755
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发表时间：
1985
影响因子：
3
通讯作者：
N. Manojlović
中科院分区：
文献类型：
--
作者：
Ulrich Ewers;A. Brockhaus;R. Dolgner;I. Freier;E. Jermann;Alfred Bernard;Renate Stiller;R. Hahn;N. Manojlović
进行了一项流行病学研究，以评估在联邦共和国德国镉污染地区发现的镉环境污染是否与非职业性暴露于重金属的人群中肾功能障碍生物学体征的患病率增加有关。这项研究是在两个已知受到镉、铅和其他重金属高度污染的工业区进行的，即斯托尔贝格和杜伊斯堡。杜塞尔多夫被选为参考地区。作为一个研究人群，我们选择了65岁和66岁的妇女（n= 286）谁花了大部分的生活在这些领域之一。血液和尿液中的平均镉水平（CdU）显示出显着差异，镉暴露的顺序斯托尔贝格>杜伊斯堡>杜塞尔多夫。平均而言，Stolberg组的血清肌酐水平显著高于杜伊斯堡和杜塞尔多夫组。然而，在低分子量蛋白（β2-微球蛋白、视黄醇结合蛋白）、白蛋白尿、总蛋白尿、氨基酸尿、磷酸盐尿和一些其他生物学结果的尿排泄方面，未观察到研究人群之间的显著差异。同样，三个研究组中临床确诊的高血压患病率以及高血压受试者的相对频率（收缩压≥ 160 mmHg和/或舒张压≥ 95 mmHg）无显著差异。CdU与肾小管蛋白尿在0.1 ~ 5.2 μg/g肌酐范围内无明显相关性。然而，当CdU水平> 2 μg/g肌酐时，白蛋白尿倾向于增加。
An epidemiological study was performed to assess whether environmental pollution by cadmium as found in cadmium-polluted areas of the Federal Republic of Germany is associated with an increased prevalence of biological signs of kidney dysfunction in population groups non-occupationally exposed to heavy metals. The study was run in two industrial areas known to be highly contaminated by cadmium, lead and other heavy metals, viz. Stolberg and Duisburg. Dusseldorf was selected as a reference area. As a study population we selected 65- and 66-year-old women (n= 286) who had spent the major part of their lives in one of these areas. The average cadmium levels in blood (CdB) and urine (CdU) revealed significant differences in exposure to cadmium in the order Stolberg > Duisburg > Düsseldorf. Serum creatinine levels were, on average, significantly higher in the Stolberg group than in the Duisburg and Düsseldorf groups. However, with respect to the urinary excretion of low molecular weight proteins (β2-microglobulin, retinol-binding protein), albuminuria, total proteinuria, aminoaciduria, phosphaturia and some other biological findings, no significant differences between the study populations were noted. Similarly, the prevalence of clinically-confirmed hypertension as well as the relative frequency of hypertensive subjects (systolic ≥ 160 and/or diastolic ≥ 95 mm Hg) did not differ significantly among the three study groups. There was no exposure-reponse relationship between CdU and tubular proteinuria in the range of the CdU-levels found (0.1 to 5.2 μg/g creatinine). However, albuminuria tended to be increased at CdU levels > 2 μg/g creatinine.