Hippocampus and olfactory discrimination learning: effects of entorhinal cortex lesions on olfactory learning and memory in a successive-cue, go-no-go task.
Hippocampus and olfactory discrimination learning: effects of entorhinal cortex lesions on olfactory learning and memory in a successive-cue, go-no-go task.
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海马和嗅觉辨别学习：内嗅皮层损伤对连续提示、走不走任务中嗅觉学习和记忆的影响。
DOI：
10.1037//0735-7044.105.1.111
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发表时间：
1991
影响因子：
1.9
通讯作者：
Lynch,G
中科院分区：
文献类型：
--
作者：
Otto,T;Schottler,F;Staubli,U;Eichenbaum,H;Lynch,G
三个实验评估的影响，内嗅皮层病变的嗅觉学习和记忆，使用连续线索嗅觉辨别范式。与其他使用错误线索范式的研究结果相反，内嗅皮层的损伤促进了大鼠对个体气味辨别问题的获得，尽管训练有限，但在短（24小时）和长（65天）保留间隔内对个体气味的记忆没有损害。当考虑到与以前的观察促进或损伤后，海马系统的学习，目前的数据表明，海马优先参与多种刺激之间的编码关系。通过这种解释，促进性能是由于海马系统功能障碍和任务条件之间的相互作用，阻碍了线索之间的直接比较。
Three experiments assessed the effect of entorhinal cortex lesions on olfactory learning and memory using a successive-cue olfactory discrimination paradigm. In contrast to the results of other studies that used a simultaneous-cue paradigm, lesions of the entorhinal cortex facilitated rats' acquisition of individual odor discrimination problems, with no impairment in memory for the individual odors across both short (24-hr) and long (65-day) retention intervals and despite limited training. When considered together with previous observations of facilitation or impairment in learning after damage to the hippocampal system, the present data suggest that the hippocampus is preferentially involved in encoding relations among multiple stimuli. By this account, facilitation of performance is due to an interaction between hippocampal system dysfunction and task conditions that hinder direct comparisons among cues.