GROWTH FACTOR-REGULATED PATHWAYS IN EPITHELIAL-CELL PROLIFERATION
GROWTH FACTOR-REGULATED PATHWAYS IN EPITHELIAL-CELL PROLIFERATION
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DOI：
10.1164/ajrccm/142.6_pt_2.s7
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发表时间：
1990-12-01
期刊：
影响因子：
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通讯作者：
KRAUS, MH
中科院分区：
文献类型：
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作者：
AARONSON, SA;RUBIN, JS;KRAUS, MH
调节上皮细胞正常生长的PSTHW8的实验表明增殖所需的两个生长因子信号的存在。一种途径受 IGF-1 或高胰岛素浓度的激活。另一种则由EGF、TOFa或FGFf8的成员触发，包括最近发现的上皮细胞特异性生长因子、角膜细胞生长因子(KGF)。 III 表达模式在“'''0luggelll thet KGFpleye en luggelll thet KGFpleye en 不适当的正常生理作用 es e 上皮细胞 prollf8retlon 的 Itromel 效应器。癌基因，它代表基因的组成型形式参与生长·f8etor Ilgnellng path·weys，apeclflcelly ebrogete 的要求例如，EGF 基因的例子包括 erbB1EGF 受体末端 erbB·2，其编码结构相关的受体蛋白末端，经常在上皮细胞中使用还原的末端/或过度表达。
IlMIstlgstlons of the psthw8yll reguletlng normel growth of eplthellel cells hevel'1lV8eled the existence of two meJorgrowth-f8etor slgnellng cescedes required for prollferetlon. One pethway Is ectlveted by IGF-1 or high Insulin concentration. The other Is triggered by EGF, TOFa, or members of the FGFf8mlly, Including the recently dlecovered eplthellel-cell· speclflc growth f8ctor, dellgnet· ed keretlnocyte growth f8etor (KGF). III expresllon plttern In"'''0luggelll thet KGFpleye en lmpertent normel physiologic role es e Itromel effector of eplthellel cell prollf8retlon. Oncogenel, which represent constitutively eetlveted forme of genel crltlcelly Involved In growth· f8etor Ilgnellng path· weys, apeclflcelly ebrogete the requirement for mltogenl of the EGF pethway. Exemplel of sueh genes Include the erbBlEGF receptor end erbB· 2, which encode Itructurally releted receptor pro· telns end ere often empllfled end/or overexpreeeed In eplthellel mellgnenclee. Employing reduced