Haplotype frequencies of eight Y-chromosome STR loci in Barcelona (North-East Spain)
Haplotype frequencies of eight Y-chromosome STR loci in Barcelona (North-East Spain)
复制标题
巴塞罗那（西班牙东北部）八个 Y 染色体 STR 位点的单倍型频率
DOI：
10.1007/s004140050025
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发表时间：
1999
影响因子：
2.1
通讯作者：
E. Huguet
中科院分区：
文献类型：
--
作者：
M. Gené;N. Borrego;A. Xifró;E. Piqué;P. Moreno;E. Huguet
摘要 在巴塞罗那（西班牙东北部）的人口样本中确定了八个 Y 染色体短串联重复 (STR) 位点的单倍型频率。 PCR扩增和变性PAGE电泳后，对DYS19、DYS388、DYS389 I/II、DYS390、DYS391、DYS392和DYS393位点进行分型。 223名受试者可以形成完整的8个“Y染色体STR单倍型”，其中观察到137个不同的单倍型。 13% 的样本共有最常见的单倍型，而 108 个单倍型是独特的。辨别能力为61.5%，基因多样性为0.978。从法医学的角度来看，组合的多态性提供了很高的诊断效率。
Abstract Haplotype frequencies for eight Y-chromosomal short tandem repeat (STR) loci were determined in ¶a population sample from Barcelona (NE Spain). After PCR amplification and denaturing PAGE electrophoresis, DYS19, DYS388, DYS389 I/II, DYS390, DYS391, DYS392 and DYS393 loci were typed. Complete eight ¶Y-chromosomal STRs haplotypes could be formed for 223 subjects, among which 137 different haplotypes were observed. The most common haplotype was shared by 13% of the sample, while 108 haplotypes were unique. The discrimination capacity was 61.5% and the gene diversity was 0.978. From the forensic point of view the combined polymorphisms provide a high diagnostic efficiency.