Gestational age-related changes in the fetal functional connectome: in utero evidence for the global signal.
Gestational age-related changes in the fetal functional connectome: in utero evidence for the global signal.
复制标题
胎儿功能连接组中与孕龄相关的变化：全球信号的子宫内证据。
DOI：
10.1093/cercor/bhac209
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Limperopoulos,Catherine
中科院分区：
文献类型：
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作者：
Kim,Jung-Hoon;DeAsis-Cruz,Josepheen;Cook,KevinM;Limperopoulos,Catherine
人类的大脑在妊娠第三周开始发育，并在整个怀孕过程中迅速生长和成熟。与胎儿结构神经发育相比，人们对子宫内出现的功能连接知之甚少。在这里，我们研究了95名健康胎儿的110个静息状态功能磁共振成像扫描的大型数据集，研究了妊娠中期和妊娠晚期与胎龄（GA）相关的脑功能连接的体内变化。利用表征相似性分析（一种揭示高阶空间成对相似性的多变量分析技术），我们发现胎儿功能连接组模式的被试间相似性与被试间GA差异密切相关（r= 0.28，P< 0.01），并且功能连接组的GA敏感性偏侧，尤其是在额叶区域。我们的分析还揭示了对预测年龄至关重要的连接子网络（平均绝对误差= 2.72周）；个体胎儿的功能连接体模式可靠地预测其GA （r= 0.51，P< 0.001）。最后，我们确定了跟踪胎儿脑成熟的主要脑网络。主网络表现出类似于成人大脑整体信号的全球同步模式。
The human brain begins to develop in the third gestational week and rapidly grows and matures over the course of pregnancy. Compared to fetal structural neurodevelopment, less is known about emerging functional connectivity in utero. Here, we investigated gestational age (GA)-associated in vivo changes in functional brain connectivity during the second and third trimesters in a large dataset of 110 resting-state functional magnetic resonance imaging scans from a cohort of 95 healthy fetuses. Using representational similarity analysis, a multivariate analytical technique that reveals pair-wise similarity in high-order space, we showed that intersubject similarity of fetal functional connectome patterns was strongly related to between-subject GA differences (r= 0.28,P< 0.01) and that GA sensitivity of functional connectome was lateralized, especially at the frontal area. Our analysis also revealed a subnetwork of connections that were critical for predicting age (mean absolute error = 2.72 weeks); functional connectome patterns of individual fetuses reliably predicted their GA (r= 0.51,P< 0.001). Lastly, we identified the primary principal brain network that tracked fetal brain maturity. The main network showed a global synchronization pattern resembling global signal in the adult brain.