Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.
Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.
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DOI：
10.1146/annurev-physiol-021113-170358
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发表时间：
2015
影响因子：
18.2
通讯作者：
Baki L
中科院分区：
文献类型：
--
作者：
Logothetis DE;Petrou VI;Zhang M;Mahajan R;Meng XY;Adney SK;Cui M;Baki L
阴离子磷脂是质膜内小叶的关键成分，确保跨膜蛋白的适当膜拓扑结构。此外，在真核生物中，带负电荷的磷酸肌醇不仅通过其水解产物而且通过直接控制跨膜蛋白功能来充当关键信号。磷脂酰肌醇直接控制离子通道和转运蛋白的活性是磷脂-蛋白质相互作用在膜蛋白功能控制中至关重要的最有说服力的例子。此外，第二信使，如[Ca 2 +]i，或翻译后修饰，如磷酸化，可以直接或变构微调磷脂-蛋白质相互作用和调节活性。膜蛋白结构测定的最新进展使研究人员能够获得离子通道与磷酸肌醇的复合物，并使用计算和实验方法来探测脂质-蛋白质相互作用控制活性和非活性蛋白质状态的动态机制。
Anionic phospholipids are critical constituents of the inner leaflet of the plasma membrane, ensuring appropriate membrane topology of transmembrane proteins. Additionally, in eukaryotes, the negatively charged phosphoinositides serve as key signals not only through their hydrolysis products but also through direct control of transmembrane protein function. Direct phosphoinositide control of the activity of ion channels and transporters has been the most convincing case of the critical importance of phospholipid-protein interactions in the functional control of membrane proteins. Furthermore, second messengers, such as [Ca2+]i, or posttranslational modifications, such as phosphorylation, can directly or allosterically fine-tune phospholipid-protein interactions and modulate activity. Recent advances in structure determination of membrane proteins have allowed investigators to obtain complexes of ion channels with phosphoinositides and to use computational and experimental approaches to probe the dynamic mechanisms by which lipid-protein interactions control active and inactive protein states.
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影响因子：
4.8
作者：
Abderemane-Ali, Fayal;Es-Salah-Lamoureux, Zeineb;Loussouarn, Gildas
通讯作者：
Loussouarn, Gildas
影响因子：
11.4
作者：
Chemin, J;Girard, C;Lazdunski, M
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Lazdunski, M
影响因子：
56.9
作者：
Baukrowitz, T;Schulte, U;Fakler, B
通讯作者：
Fakler, B
影响因子：
25
作者：
Berman, Diego E.;Dall'Armi, Claudia;Di Paolo, Gilbert
通讯作者：
Di Paolo, Gilbert
影响因子：
5.3
作者：
Allen, Duane;Fakler, Bernd;Adelman, John P.
通讯作者：
Adelman, John P.