Connectivity gradients between the default mode and attention control networks.
Connectivity gradients between the default mode and attention control networks.
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DOI：
10.1089/brain.2011.0007
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发表时间：
2011
影响因子：
3.4
通讯作者：
Yurgelun-Todd D
中科院分区：
文献类型：
--
作者：
Anderson JS;Ferguson MA;Lopez-Larson M;Yurgelun-Todd D
功能成像研究表明，在需要注意力的任务中，默认模式网络的活动减少。这种抑制作用背后的网络电路机制尚不清楚。提出的假设包括在右前脑岛的注意“开关”和默认模式和注意控制网络之间的相互抑制。我们分析了来自26个地点的1278名受试者的静息状态BOLD数据，并以大约5毫米的分辨率构建了覆盖灰质的7266个roi之间功能连接的全脑图。基于与6个已发布的种子位置的相关性，确定了默认模式网络和注意控制网络的roi。注意控制网络和默认模式网络之间存在空间异质性，两个网络的每个枢纽的梯度平滑变化，从弱但显著反相关到正相关。这些梯度在3个不同的受试者组中重现。在两个网络的主要枢纽中发现了反相关的子区域。在青春期晚期和成年早期，网络间连通性梯度随着年龄的增长而增强，默认模式网络边界的锐化，脑岛和扣带与额顶叶注意区域的整合，以及默认模式和注意控制网络之间的相关性随着年龄的增长而减弱。
Functional imaging studies have shown reduced activity within the default mode network during attention-demanding tasks. The network circuitry underlying this suppression remains unclear. Proposed hypotheses include an attentional “switch” in the right anterior insula and reciprocal inhibition between the default mode and attention control networks. We analyzed resting state BOLD data from 1278 subjects from 26 sites and constructed whole brain maps of functional connectivity between 7266 ROIs covering the gray matter at approximately 5 mm resolution. ROIs belonging to the default mode network and attention control network were identified based on correlation to six published seed locations. Spatial heterogeneity of correlation between the default mode and attention control networks was observed, with smoothly varying gradients in every hub of both networks that ranged smoothly from weakly but significantly anticorrelated to positively correlated. Such gradients were reproduced in 3 separate groups of subjects. Anticorrelated subregions were identified in major hubs of both networks. Between-network connectivity gradients strengthen with age during late adolescence and early adulthood, with associated sharpening of the boundaries of the default mode network, integration of the insula and cingulate with frontoparietal attentional regions, and decreasing correlation between the default mode and attention control networks with age.