The Folate Concentration and/or Folic Acid Metabolites in Plasma as Factor for COVID-19 Infection
The Folate Concentration and/or Folic Acid Metabolites in Plasma as Factor for COVID-19 Infection
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DOI：
10.3389/fphar.2020.01062
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发表时间：
2020-07-16
影响因子：
5.6
通讯作者：
Espinosa-Tanguma, Ricardo
中科院分区：
文献类型：
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作者：
Acosta-Elias, Jesus;Espinosa-Tanguma, Ricardo
孕妇似乎比育龄妇女更容易感染传染病。据加州公共卫生部称，2009 年流感爆发期间，孕妇住院的可能性是育龄非孕妇的 9.6 倍。相比之下，据报道，在英国住院的 16,749 名 COVID-19 患者中，孕妇因感染 SARS-CoV-2 而需要住院治疗的概率与非孕妇相比为 0.95。因此，9.6/0.95 = 10.10，这使我们得出结论，孕妇因 SARS-CoV-2 感染而住院的可能性是 2009 年 H1N1 大流行的 10.10 倍。怀孕期间补充叶酸可能是保护这些患者免受 SARS-CoV-2 感染的因素。两篇使用信息模拟的独立论文证明叶酸可以减少这种病毒的复制。其中一项研究表明，叶酸可以抑制病毒进入宿主细胞所需的弗林蛋白酶，而另一项研究则解释说，叶酸可以使病毒复制所需的蛋白酶 3CL(pro) 失活。尽管如此，叶酸阻断两种不同蛋白质的可能性非常低，因此叶酸在 COVID-19 大流行期间明显保护孕妇的机制尚未确定。
Pregnant women appear to be more susceptible to infectious diseases than women in reproductive age. According to the California Department of Public Health pregnant women were 9.6-folds more likely to be hospitalized during the 2009 influenza outbreak when compared to non-pregnant women in reproductive age. In contrast, it was reported that of 16,749 COVID-19 patients that were hospitalized in the UK, the probability for pregnant women to require in-patient care due to infection by SARS-CoV-2 was 0.95 versus non-pregnant women. Therefore 9.6/0.95 = 10.10, which brings us to the conclusion that pregnant women are 10.10-folds less likely to be hospitalized for a SARS-CoV-2 infection than for the 2009 H1N1 pandemic. Folic acid supplementation during pregnancy could be the factor that is protecting these patients against SARS-CoV-2 infection. Two independent papers that used informatic simulation proved that folic acid reduced the replication of this virus. One of them showed that folic acid inhibits the furin protease which the virus needs in order to enter its host cell, while the other one explained that folic acid inactivates protease 3CL(pro), a protein that the virus needs to replicate. Nonetheless the probability that folic acid blocks two different proteins is very low, therefore the mechanism by which folic acid has apparently protected pregnant women during the COVID-19 pandemic has not been determined.