Macular pigment shows ringlike structures
Macular pigment shows ringlike structures
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DOI：
10.1167/iovs.05-0663
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发表时间：
2006-02-01
影响因子：
4.4
通讯作者：
van Norren, D
中科院分区：
文献类型：
--
作者：
Berendschot, TTJM;van Norren, D
目的.黄斑色素的空间分布通常被假定为在周边单调地降低到非常低的值。然而，有迹象表明，这幅图景可能过于简单。本研究的目的是检查黄斑色素光学密度的空间分布。使用定制的扫描激光检眼镜在53名健康受试者中采集了488和514 nm氩激光波长下的眼底反射率和自体荧光图。因为透镜和黄斑色素是该波长区域中仅有的吸收体，所以在两个波长处对数反射率和对数自发荧光的数字减法提供了两个反射率和的总和的密度图。在大约一半的受试者中，我们观察到一个明显的环形图案，平均距离为0.7的中央凹。在少数受试者中，环的光密度甚至比中心峰更大。一个简单的模型与指数衰减的密度作为偏心率的函数，结合高斯分布的环形图案，产生了很好的描述数据的两种方法。两种方法的中心峰和高斯环的宽度以及环峰的偏心率相似。环的突出度不依赖于年龄和性别。反射图和自发荧光图均显示黄斑色素分布的环形图案，其可能遵循内丛状层。
PURPOSE. The spatial distribution of macular pigment is generally assumed to monotonously decrease to very low values in the periphery. However, there are indications that this picture may be too simple. The purpose of this study was to examine the spatial distribution of the macular pigment optical density.METHODS. Fundus reflectance and autofluorescence maps at 488 and 514 nm Argon laser wavelengths were acquired in 53 healthy subjects with a custom-built scanning laser ophthalmoscope. Because the lens and the macular pigment are the only absorbers in this wavelength region, digital subtraction of log reflectance and log autofluorescence at the two wavelengths provides density maps of the sum of both absorbers.RESULTS. In approximately half of the subjects, we observed a distinct ring pattern at a mean distance of 0.7 of the fovea. In a few subjects, the ring had an even larger optical density than did the central peak. A simple model with an exponentially decaying density as a function of eccentricity, in combination with a Gaussian-distributed ring pattern, yielded a good description of the data for both methods. The widths of the central peak and the Gaussian ring, and also the eccentricity at which the ring peaks, were similar for both methods. The prominence of the ring did not depend on age and gender.CONCLUSIONS. Both reflectance and autofluorescence maps showed ring patterns in the distribution of the macular pigment, which probably follow the inner plexiform layer.