Association of hypertension and obesity with HIV and antiretroviral therapy in a rural tertiary health center in Nigeria: a cross-sectional cohort study
Association of hypertension and obesity with HIV and antiretroviral therapy in a rural tertiary health center in Nigeria: a cross-sectional cohort study
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DOI：
10.2147/vhrm.s58449
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发表时间：
2014-01-01
影响因子：
2.9
通讯作者：
Olamoyegun, Adeyemi Michael
中科院分区：
文献类型：
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作者：
Ogunmola, Olarinde Jeffrey;Oladosu, Olatunji Yusuf;Olamoyegun, Adeyemi Michael
背景资料：尼日利亚和非洲关于肥胖和高血压对艾滋病毒感染者心血管风险的影响的研究很少。本研究调查了高血压和肥胖的患病率及其与HIV感染和抗逆转录病毒治疗（ART）的关系。方法：我们在尼日利亚的一个农村三级卫生中心进行了一项横断面队列研究。收集的数据包括人口统计学变量，血压，体重指数（BMI），月收入，教育程度，艾滋病毒感染状况和ART治疗，治疗持续时间，和CD 4 T淋巴细胞计数。有153（38.0%）艾滋病毒阴性受试者（42.5%男性，57.5%女性;平均年龄：35.5 ± 7.6岁），120（29.8%）HIV阳性药物初治受试者（42.5%男性，57.5%女性;平均年龄：36.5 ± 9.1岁），130（32.2%）服用抗逆转录病毒药物的HIV阳性受试者（33.1%男性，66.9%女性;平均年龄：38.6 ± 8.0岁）。HIV阴性受试者的高血压患病率为13.7%，HIV阳性药物初治受试者为19.0%，HIV阳性ART受试者为12.3%。肥胖的患病率在HIV阴性组中为15.9%，在HIV阳性药物初治组中为3%，在HIV阳性ART组中为8%。多因素回归分析显示高血压与HIV感染（P=0.293）和ART感染（P=0.587）无相关性。相比之下，BMI与HIV状态有很强的关系（比值比：0.281; 95%置信区间：0.089-0.884; P=0.030），但与ART状态无关（P=0.593）。结论：HIV感染或ART感染与高血压无关。与HIV阴性受试者相比，HIV感染与较低的BMI和较低的肥胖患病率相关。
Background: There are few studies from Nigeria and Africa regarding the contribution of obesity and hypertension to cardiovascular risk in HIV-infected patients. This study investigates the prevalence of hypertension and obesity and their association with HIV infection and antiretroviral treatment (ART).Methods: We conducted a cross-sectional cohort study in a rural tertiary health center in Nigeria. The data collected included demographic variables, blood pressure, body mass index (BMI), monthly income, educational attainment, HIV status and ART treatment, duration of treatment, and CD4 T-lymphocyte count.Results: A total of 403 participants met the inclusion criteria. There were 153 (38.0%) HIV-negative subjects (42.5% male, 57.5% female; mean age: 35.5 +/- 7.6 years), 120 (29.8%) HIV-positive drug-naive subjects (42.5% male, 57.5% female; mean age: 36.5 +/- 9.1 years), and 130 (32.2%) HIV-positive subjects taking antiretroviral drugs (33.1% male, 66.9% female; mean age: 38.6 +/- 8.0 years). The prevalence of hypertension was 13.7% in HIV-negative subjects, 19.0% in HIV-positive drug-naive subjects, and 12.3% in HIV-positive ART subjects. The prevalence of obesity was 15.9% in the HIV-negative group, 3% in the HIV-positive drug-naive group, and 8% in the HIV-positive ART group. Multivariate regression analysis showed no relationship between hypertension and HIV status (P=0.293) or ART status (P=0.587). In contrast, BMI showed a strong relationship with HIV status (odds ratio: 0.281; 95% confidence interval: 0.089-0.884; P=0.030) but not with ART status (P=0.593). BMI was a significant predictor of hypertension.Conclusion: HIV or ART status was not associated with hypertension. HIV infection was associated with a lower BMI, and a lower prevalence of obesity compared with HIV-negative subjects.