Primate-specific alterations in neural stem/progenitor cells in the aged hippocampus
Primate-specific alterations in neural stem/progenitor cells in the aged hippocampus
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DOI：
10.1016/j.neurobiolaging.2008.12.011
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发表时间：
2011-01-01
影响因子：
4.2
通讯作者：
Hisatsune, Tatsuhiro
中科院分区：
文献类型：
--
作者：
Aizawa, Ken;Ageyama, Naohide;Hisatsune, Tatsuhiro
在海马的齿状回中，新的神经元在整个生命过程中从神经干/祖细胞（NPC）产生。随着年龄的增长，神经发生的速度呈指数级下降，这可能是动物和人类年龄依赖性认知能力下降的部分原因。然而，很少有研究分析衰老过程中NPC的变化，特别是在灵长类动物中。在这里，我们通过FABP 7，Sox 2和GFAP的三重免疫染色标记NPC，发现它们的数量在老年猕猴（>20岁）中减少，但在老年小鼠中没有。重要的是，我们只在老年猴中观察到NPC的明显形态学改变。在老年猴子的海马中，NPC的过程很短，水平而不是垂直。尽管有这些变化，老年猴中NPC的增殖率与年轻猴相似。因此，形态学改变不影响NPC的增殖速率，但可能参与老年灵长类动物（包括老年人）NPC的维持。(C)2008年爱思唯尔公司All rights reserved.
In the dentate gyrus of the hippocampus, new neurons are generated from neural stem/progenitor cells (NPCs) throughout life. As aging progresses, the rate of neurogenesis decreases exponentially, which might be responsible, in part, for age-dependent cognitive decline in animals and humans. However, few studies have analyzed the alterations in NPCs during aging, especially in primates. Here, we labeled NPCs by triple immunostaining for FABP7, Sox2, and GFAP and found that their numbers decreased in aged macaque monkeys (>20 years old), but not in aged mice. Importantly, we observed marked morphological alterations of the NPCs in only the aged monkeys. In the aged monkey hippocampus, the processes of the NPCs were short and ran horizontally rather than vertically. Despite these alterations, the proliferation rate of the NPCs in aged monkeys was similar to that in young monkeys. Thus, morphological alterations do not affect the proliferation rate of NPCs, but may be involved in the maintenance of NPCs in aged primates, including elderly humans. (C) 2008 Elsevier Inc. All rights reserved.