PREDICTIVE RESPONSES IN PARKINSONS-DISEASE - MANUAL KEYPRESSES AND SACCADIC EYE-MOVEMENTS TO REGULAR STIMULUS EVENTS
PREDICTIVE RESPONSES IN PARKINSONS-DISEASE - MANUAL KEYPRESSES AND SACCADIC EYE-MOVEMENTS TO REGULAR STIMULUS EVENTS
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DOI：
10.1136/jnnp.52.9.1033
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发表时间：
1989-09-01
影响因子：
11
通讯作者：
KENNARD, C
中科院分区：
文献类型：
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作者：
CRAWFORD, T;GOODRICH, S;KENNARD, C
在一项巧合计时任务中，帕金森患者和对照组被要求将按键与视觉信号同步，而视觉信号之前有一系列常规的警告信号。虽然帕金森氏症组先前在传统的简单反应时间任务中表现出较慢的反应，但他们能够产生与对照组一样接近目标起点的预测性反应，“但表现出更大的可变性”。在第二个实验中，帕金森病患者和对照组对两个固定位置之间间隔一定时间的视觉目标进行跳眼运动。经过几次试验后，所有受试者都倾向于在目标偏移之前开始进行预测性扫视。然而，帕金森病组发展这种策略的速度较慢，当他们这样做时，他们的扫视变得比对照组低得多。两组人都能保持预测反应，即使当视觉目标消失，反应由蜂鸣器计时。我们的结论是，至少在某些情况下，帕金森患者能够通过眼睛和手做出预测反应，但这种反应在执行中往往是不准确的。反过来，这可能会使帕金森患者无法预测运动。
In a coincidence timing task, Parkinsonian patients and a control group were instructed to synchronise a keypress with the onset of a visual signal which had been preceded by a regular train of warning signals. Although the Parkinsonian group had previously exhibited slower reactions in a conventional simple reaction-time task, they were able to generate predictive responses that fell as close to the target onset as the controls'' but showed greater variability. In a second experiment, Parkinsonian patients and control made saccadic eye movements to a visual target that stepped at regular intervals between two fixed locations. After a few trials all the subjects tended to make predictive saccades that were initiated before the target excursion. However, the Parkinsonian group were slower to develop this strategy and when they did their saccades became considerably more hypometric than those of the controls. Both groups were able to maintain predictive responding even when the visual target disappeared and responses were paced by a buzzer. We concluded that Parkinsonian patients are capable of initiating predictive responses of the eye and the hand, at least in some circumstances, but such responses tend to be inaccurate in execution. This, in turn, may dispose the Parkinsonian patient against predictive movement.