Intestinal mucosal MMP-1 - a prognostic factor in colon cancer
Intestinal mucosal MMP-1 - a prognostic factor in colon cancer
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DOI：
10.3109/00365521.2012.708939
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发表时间：
2013-05-01
影响因子：
1.9
通讯作者：
Angenete, Eva
中科院分区：
文献类型：
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作者：
Langenskiold, Marcus;Ivarsson, Marie-Lois;Angenete, Eva
客观的。有证据表明转化生长因子-β(1) (TGF-β(1)) 和基质金属蛋白酶 (MMP) 在结直肠癌的肿瘤侵袭和进展中发挥重要作用。本研究的目的是评估它们在预测癌症特异性生存 (CSS) 方面的效用。材料和方法。前瞻性纳入了 136 名接受结直肠癌根治性手术的患者。从肿瘤和无肿瘤肠粘膜中取出样本，并使用 ELISA 评估组织中的蛋白质水平。对患者进行 CSS 随访。所有纳入患者的中位随访时间为 65 个月（范围：45-92 个月）。主要结果指标是 CSS。结果。单变量分析显示，T 分期、淋巴结受累以及无瘤粘膜组织中高水平的 MMP-1 和 MMP-9 与结肠癌的 CSS 显着相关。在多变量分析中，MMP-1 和 N 状态维持了这种预后强度。结论。结果表明，MMP-1 与结肠癌患者的 CSS 独立相关。此外，一个可能的临床意义是，无肿瘤粘膜中 MMP-1 蛋白的表达可以识别 CSS 较差、需要加强辅助治疗的结肠癌患者。
Objective. There is evidence that transforming growth factor-beta(1) (TGF-beta(1)) and matrix metalloproteinases (MMPs) play an important role in tumor invasion and progression in colorectal cancer. The aim of this study was to assess their utility in prediction of cancer-specific survival (CSS). Materials and methods. 136 patients undergoing curative surgery for colorectal carcinoma were prospectively included. Samples were taken from tumor and tumor-free intestinal mucosa and ELISA was used to assess protein levels in the tissues. Patients were followed for CSS. The median follow-up time for all included patients was 65 months (range: 45-92). The main outcome measure was CSS. Results. T stage, lymph node involvement and high levels of MMP-1 as well as MMP-9 in tumor-free mucosa tissue were significantly associated with CSS in colon cancer in univariate analysis. This prognostic strength was maintained for MMP-1 and N-status in multivariate analysis. Conclusions. The results indicate that MMP-1 is independently associated with CSS in patients with colon cancer. Furthermore, a possible clinical implication is that MMP-1 protein expression in tumor-free mucosa could identify colon cancer patients with poor CSS in need of more intensified adjuvant treatment.