Mechanisms of Nucleosome Dynamics In Vivo
Mechanisms of Nucleosome Dynamics In Vivo
复制标题
DOI：
10.1101/cshperspect.a026666
复制
发表时间：
2016-09-01
影响因子：
5.4
通讯作者：
Henikoff, Steven
中科院分区：
文献类型：
--
作者：
Henikoff, Steven
核小体的功能是将DNA紧密包装到染色体中，但核小体景观在复制、转录和修复等活跃过程中被破坏。许多负责染色质调节的蛋白质在癌症中经常突变的认识引起了人们对染色质动力学的关注;然而，核小体被破坏和重新组装的基本机制尚未完全理解。在这里，我提出了一个概述的染色质动力学已阐明模式生物，其中我们的理解是最先进的。对正常发育过程中染色质动力学的基本了解可以为理解这种机制在肿瘤发生过程中如何出错提供背景。
Nucleosomes function to tightly package DNA into chromosomes, but the nucleosomal landscape becomes disrupted during active processes such as replication, transcription, and repair. The realization that many proteins responsible for chromatin regulation are frequently mutated in cancer has drawn attention to chromatin dynamics; however, the basic mechanisms whereby nucleosomes are disrupted and reassembled is incompletely understood. Here, I present an overview of chromatin dynamics as has been elucidated in model organisms, in which our understanding is most advanced. A basic understanding of chromatin dynamics during normal developmental processes can provide the context for understanding how this machinery can go awry during oncogenesis.