Polysaccharides derived from natural sources regulate triglyceride and cholesterol metabolism: a review of the mechanisms
Polysaccharides derived from natural sources regulate triglyceride and cholesterol metabolism: a review of the mechanisms
复制标题
天然来源的多糖调节甘油三酯和胆固醇代谢：机制综述
DOI：
10.1039/c8fo02375a
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发表时间：
2019
期刊：
影响因子：
6.1
通讯作者：
Ren Rendong
中科院分区：
文献类型：
--
作者：
Wu Qingqian;Wang Qintao;Fu Junfen;Ren Rendong
近年来，随着人们生活方式的改变，糖尿病的发病率急剧上升。大量研究表明天然多糖具有降血脂作用。本文就多糖类药物引起的糖尿病的病因和机制进行综述，以期更好地了解多糖类药物如何缓解糖尿病。天然多糖通过ATGL-（PPAR-α）/（PGC-1α）、（SREBP-1c）-ACC/FAS和ACC-CPT 1信号通路降低甘油三酯水平，并通过（SREBP-2）-HMGCR和胆汁酸生物合成通路发挥降胆固醇作用。腺苷一磷酸激活蛋白激酶（AMPK）的激活是多糖同时调节糖脂代谢的关键因素。本文还对多糖类物质增加内源性H_2S产生的新发现进行了讨论。总的来说，目前可用的数据表明，天然多糖可能被开发为新的和安全的降脂药物，但在这个长期的过程中需要进一步的机制和临床研究。
With great changes in people's lifestyles, the incidence of hyperlipidaemia has dramatically increased in recent years. Numerous studies have demonstrated that natural polysaccharides have lipid lowering effects. In this review, the causes and mechanisms of hyperlipidaemia are discussed in order to better understand how polysaccharides alleviate hyperlipidaemia. Natural polysaccharides reduce triglyceride levels through ATGL–(PPAR-α)/(PGC-1α), (SREBP-1c)–ACC/FAS and ACC–CPT1 signal pathways, and exert cholesterol lowering effects via (SREBP-2)-HMGCR and bile acid biosynthesis pathways. Activation of adenosine monophosphate-activated protein kinase (AMPK) is the key factor that mediated the simultaneous regulation of both glucose and lipid metabolism by polysaccharides. The new discovery of polysaccharides increasing the production of endogenous H2S, an important physiological gaseous signaling molecule, is also discussed. Collectively, the current available data suggest that natural polysaccharides could be potentially developed as new and safe lipid-lowering drugs; yet further mechanistic and clinical studies are required during this long-term process.